Seroatlas · Human Serome Atlas

BPIFA2

BPI fold-containing family A member 2

Also known as: bA49G10.1, BPIA2_HUMAN, C20orf70, PSP, SPLUNC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DR5
Gene: BPIFA2
Ensembl: ENSG00000131050
Chromosome: 20
Canonical length: 249 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q96DR5|BPIFA2
     1  MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT LKGILEKLKV
    61  DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF GLKISNSLIL DVKAEPIDDG
   121  KGLNLSFPVT ANVTVAGPII GQIINLKASL DLLTAVTIET DPQTHQPVAV LGECASDPTS
   181  ISLSLLDKHS QIINKFVNSV INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ
   241  HKTQLQTLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPIFA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 6,453 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 6,453 nTPM
epididymis: 4 nTPM
pancreas: 3.7 nTPM
testis: 1.1 nTPM
heart muscle: 0.9 nTPM
bone marrow: 0.4 nTPM

Single-cell type

salivary acinar cells: 3,985 nCPM
salivary myoepithelial cells: 995 nCPM
respiratory ionocytes: 241 nCPM
conjunctival goblet cells: 163 nCPM
neutrophils: 104 nCPM
salivary ionocytes: 100 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

defense response to bacterium

Molecular functions

lipopolysaccharide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Lipid-binding serum glycoprotein, N-terminal
Bactericidal permeability-increasing protein, alpha/beta domain superfamily
LBP / BPI / CETP family, N-terminal domain
BPI fold-containing antibacterial protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPIFA2 as an antibody target. Whether an autoantibody or antibody against BPIFA2 could matter depends on whether native BPIFA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPIFA2 is annotated as secreted, so native BPIFA2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BPIFA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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