Seroatlas · Human Serome Atlas

BPHL

Serine hydrolase BPHL

Also known as: Bph-rp, BPHL_HUMAN, MCNAA, VACVase

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WA6
Gene: BPHL
Ensembl: ENSG00000137274
Chromosome: 6
Canonical length: 291 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q86WA6|BPHL
     1  MVAVLGGRGV LRLRLLLSAL KPGIHVPRAG PAAAFGTSVT SAKVAVNGVQ LHYQQTGEGD
    61  HAVLLLPGML GSGETDFGPQ LKNLNKKLFT VVAWDPRGYG HSRPPDRDFP ADFFERDAKD
   121  AVDLMKALKF KKVSLLGWSD GGITALIAAA KYPSYIHKMV IWGANAYVTD EDSMIYEGIR
   181  DVSKWSERTR KPLEALYGYD YFARTCEKWV DGIRQFKHLP DGNICRHLLP RVQCPALIVH
   241  GEKDPLVPRF HADFIHKHVK GSRLHLMPEG KHNLHLRFAD EFNKLAEDFL Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPHL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

kidney: 103 nTPM
liver: 79 nTPM
duodenum: 32 nTPM
small intestine: 31 nTPM
epididymis: 27 nTPM
adipose tissue: 23 nTPM

Single-cell type

hepatocytes: 97 nCPM
enterocytes: 95 nCPM
adipocytes: 88 nCPM
epididymal principal cells: 59 nCPM
epididymal efferent duct absorptive cells: 53 nCPM
respiratory ciliated cells: 47 nCPM

Immune cell

memory B-cell: 18 nTPM
myeloid DC: 15 nTPM
NK-cell: 15 nTPM
basophil: 14 nTPM
intermediate monocyte: 13 nTPM
naive B-cell: 13 nTPM

Brain region

choroid plexus: 21 nTPM
white matter: 19 nTPM
cerebral cortex: 19 nTPM
hypothalamus: 19 nTPM
pons: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding
serine hydrolase activity
alpha-amino-acid esterase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPHL as an antibody target. Whether an autoantibody or antibody against BPHL could matter depends on whether native BPHL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPHL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BPHL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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