Seroatlas · Human Serome Atlas

BOD1L2

Biorientation of chromosomes in cell division protein 1-like 2

Also known as: BD1L2_HUMAN, BOD1P, FAM44C, MGC33608

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYS8
Gene
BOD1L2
Ensembl
ENSG00000228075
Chromosome
18
Canonical length
172 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell division. Predicted to be located in centrosome; cytoplasm; and kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q8IYS8|BOD1L2
     1  MADGGGGGSG GAGPASTRAS GGGGPINPAS LPPGDPQLIA IIVGQLKSRG LFDSFRRDCK
    61  ADVDTKPAYQ NLSQKADNFV STHLDKQEWN PPANDNQLHD GLRQSVVQSG RSEAGVDRIS
   121  SQVVDPKLNH IFRPQIEQII HEFLVAQKEA AVPALPPEPE GQDPPAPSQD TS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOD1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
254 nTPM

Expression across tissuesHPA

Tissue

  • testis: 254 nTPM
  • prostate: 0.2 nTPM
  • breast: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late spermatids: 8,773 nCPM
  • late primary spermatocytes: 1,853 nCPM
  • early spermatids: 1,618 nCPM
  • early primary spermatocytes: 76 nCPM
  • leydig cells: 20 nCPM
  • sertoli cells: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0.08
gnomAD missense Z
0.17
DepMap mean gene effect
0.04
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOD1L2 as an antibody target. Whether an autoantibody or antibody against BOD1L2 could matter depends on whether native BOD1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOD1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOD1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BOD1L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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