Seroatlas · Human Serome Atlas

BOD1

Biorientation of chromosomes in cell division protein 1

Also known as: BOD1_HUMAN, FAM44B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IK1
Gene: BOD1
Ensembl: ENSG00000145919
Chromosome: 5
Canonical length: 185 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid biorientation; mitotic sister chromatid cohesion, centromeric; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of Set1C/COMPASS complex and outer kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q96IK1|BOD1
     1  MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK
    61  SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV
   121  QSGMLEAGVD RIISQVVDPK LNHIFRPQIE RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP
   181  SQDTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 109 nTPM
tongue: 73 nTPM
ovary: 57 nTPM
thyroid gland: 48 nTPM
pancreas: 45 nTPM
heart muscle: 43 nTPM

Single-cell type

late spermatids: 212 nCPM
oocytes: 203 nCPM
early spermatids: 160 nCPM
extravillous trophoblasts: 98 nCPM
early primary spermatocytes: 96 nCPM
migrating cytotrophoblasts: 94 nCPM

Immune cell

eosinophil: 5.6 nTPM
naive CD4 T-cell: 3.9 nTPM
NK-cell: 3.5 nTPM
plasmacytoid DC: 3.5 nTPM
myeloid DC: 2.9 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

white matter: 37 nTPM
hypothalamus: 32 nTPM
basal ganglia: 30 nTPM
thalamus: 30 nTPM
medulla oblongata: 29 nTPM
midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.25
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOD1 as an antibody target. Whether an autoantibody or antibody against BOD1 could matter depends on whether native BOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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