Seroatlas · Human Serome Atlas

BNIP2

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Also known as: BNIP-2, BNIP2_HUMAN, Nip2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12982
Gene: BNIP2
Ensembl: ENSG00000140299
Chromosome: 15
Canonical length: 314 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q12982|BNIP2
     1  MEGVELKEEW QDEDFPIPLP EDDSIEADIL AITGPEDQPG SLEVNGNKVR KKLMAPDISL
    61  TLDPSDGSVL SDDLDESGEI DLDGLDTPSE NSNEFEWEDD LPKPKTTEVI RKGSITEYTA
   121  AEEKEDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESSQ
   181  PNYRYLMDNL FKYVIGTLEL LVAENYMIVY LNGATTRRKM PSLGWLRKCY QQIDRRLRKN
   241  LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQVD
   301  QELNGKQDEP KNEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BNIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 122 nTPM
tonsil: 43 nTPM
lymph node: 43 nTPM
adipose tissue: 41 nTPM
liver: 41 nTPM
thymus: 40 nTPM

Single-cell type

neutrophils: 264 nCPM
platelets: 195 nCPM
neutrophil progenitors: 169 nCPM
monocyte progenitors: 126 nCPM
monocytes: 112 nCPM
kupffer cells: 94 nCPM

Immune cell

neutrophil: 86 nTPM
eosinophil: 78 nTPM
basophil: 52 nTPM
classical monocyte: 47 nTPM
total PBMC: 46 nTPM
intermediate monocyte: 46 nTPM

Brain region

medulla oblongata: 30 nTPM
white matter: 29 nTPM
hypothalamus: 29 nTPM
spinal cord: 29 nTPM
thalamus: 28 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BNIP2 as an antibody target. Whether an autoantibody or antibody against BNIP2 could matter depends on whether native BNIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BNIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BNIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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