Seroatlas · Human Serome Atlas

BMP2KL

Putative BMP-2-inducible kinase-like protein

Also known as: BM2KL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9B9
Gene: BMP2KL
Canonical length: 411 aa

OverviewNCBI Gene

No narrative summary is available for BMP2KL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q5H9B9|BMP2KL
     1  MIAPSPKSSE EEGQKDEEVL QGEQGDFNDN DTEPENLGHR PLLMDSEDEE EEEKRSSDSD
    61  YEQAKAKYSD MSPVYRDKSG SGPTQDINTI LLTSAQLSSD VGVETPKQEF DIFGAVPFFA
   121  VCAQQPQQEK NEKSLPQHRF PATGLQQEEF DVFTKAPFSK KVNVQECHAV GPETHPKSID
   181  IFDFTPFQPF LTSTSKSESN EDLFGLVPFE EIMGSQQQKV KQRSLQKLSS RQRRTKQDMS
   241  KSNGKRHHGT PTSKKKTLKP TYRTPERARR HKKVGRRVSQ TSNEFVTISD SKENIGAAVT
   301  DGNDRGNVLQ LEESLLDPFG AKPFHPPDLS WHPLHQGLND IRADHNTVLP KQPRQNSLHG
   361  SFHSADVLTM DDFGAMPFTE LVVQSITLQQ SQQSQPVELD PFGAAPFPSK Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP2KL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP2KL as an antibody target. Whether an autoantibody or antibody against BMP2KL could matter depends on whether native BMP2KL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP2KL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BMP2KL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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