Seroatlas · Human Serome Atlas

BLTP1

Bridge-like lipid transfer protein family member 1

Also known as: BLTP1_HUMAN, FLJ21404, FSA, KIAA1109, KIAA1371, Tweek

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2LD37
Gene
BLTP1
Ensembl
ENSG00000138688
Chromosome
4
Canonical length
5005 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

5005 residues, UniProt reviewed canonical sequence.

>Q2LD37|BLTP1
     1  MDQRKNESIV PSITQLEDFL TEHNSNVVWL LVATILSCGW IIYLTYYNSR NVGLILTLVL
    61  NRLYKHGYIH IGSFSFSVLS GKVMVREIYY ITEDMSIRIQ DGFIIFRWWK MYNPKQKQHD
   121  PKAETRLYIT VNDFEFHVYN RSDLYGRLQE LFGLEPTIIP PKKDDDKTRE IGRTRTQSKI
   181  ERVKVKTESQ DPTSSWRSLI PVIKVNVSTG RLAFGNHYQP QTLCINFDDA FLTYTTKPPS
   241  SHLDQFMHIV KGKLENVRVM LVPSPRYVGL QNDEPPRLMG EGFVVMQSND VDIYYYMDEP
   301  GLVPEETEEN IEGEMSSEDC KLQDLPPCWG LDIVCGKGTD FNYGPWADRQ RDCLWKFFFP
   361  PDYQVLKVSE IAQPGRPRQI LAFELRMNII ADATIDLLFT KNRETNAVHV NVGAGSYLEI
   421  NIPMTVEENG YTPAIKGQLL HVDATTSMQY RTLLEAEMLA FHINASYPRI WNMPQTWQCE
   481  LEVYKATYHF IFAQKNFFTD LIQDWSSDSP PDIFSFVPYT WNFKIMFHQF EMIWAANQHN
   541  WIDCSTKQQE NVYLAACGET LNIDFSLPFT DFVPATCNTK FSLRGEDVDL HLFLPDCHPS
   601  KYSLFMLVKN CHPNKMIHDT GIPAECQSGQ KTVKPKWRNV TQEKSGWVEC WTVPSVMLTI
   661  DYTWHPIYPQ KADEQLKQSL SEMEETMLSV LRPSQKTSDR VVSSPSTSSR PPIDPSELPP
   721  DKLHVEMELS PDSQITLYGP LLNAFLCIKE NYFGEDDMYM DFEEVISSPV LSLSTSSSSG
   781  WTAVGMENDK KENEGSAKSI HPLALRPWDI TVLVNLYKVH GRLPVHGTTD GPECPTAFLE
   841  RLCFEMKKGF RETMLQLILS PLNVFVSDNY QQRPPVDEVL REGHINLSGL QLRAHAMFSA
   901  EGLPLGSDSL EYAWLIDVQA GSLTAKVTAP QLACLLEWGQ TFVFHVVCRE YELERPKSVI
   961  ICQHGIDRRF CESKLSCIPG PCPTSDDLKY TMIRLAVDGA DIYIVEHGCA TNIKMGAIRV
  1021  ANCNLHNQSV GEGISAAIQD FQVRQYIEQL NNCRIGLQPA VLRRAYWLEA GSANLGLITV
  1081  DIALAADHHS KHEAQRHFLE THDARTKRLW FLWPDDILKN KRCRNKCGCL GGCRFFGGTV
  1141  TGLDFFKLEE LTPSSSSAFS STSAESDMYY GQSLLQPGEW IITKEIPKII DGNVNGMKRK
  1201  EWENKSVGIE VERKTQHLSL QVPLRSHSSS SSSEENSSSS AAQPLLAGEK ESPSSVADDH
  1261  LVQKEFLHGT KRDDGQASIP TEISGNSPVS PNTQDKSVGQ SPLRSPLKRQ ASVCSTRLGS
  1321  TKSLTAAFYG DKQPVTVGVQ FSSDVSRSDE NVLDSPKQRR SFGSFPYTPS ADSNSFHQYR
  1381  SMDSSMSMAD SEAYFSAAEE FEPISSDEGP GTYPGRKKKK KQTQQIDYSR GSIYHSVEGP
  1441  LTGHGESIQD SRTLPFKTHP SQASFVSALG GEDDVIEHLY IVEGEKTVES EQITPQQPVM
  1501  NCYQTYLTQF QVINWSVKHP TNKRTSKSSL HRPLDLDTPT SEESSSSFEQ LSVPTFKVIK
  1561  QGLTANSLLD RGMQLSGSTS NTPYTPLEKK LADNTDDETL TEEWTLDQPV SQTRTTAIVE
  1621  VKGTVDIVLT PLVAEALDRY IEAMVHCAST RHPAAIVDDL HAKVLREAVQ NSKTTFSENL
  1681  SSKQDIRGTK TEQSTIGTTN QGQAQTNLTM KQDNVTIKGL QTNVSIPKVN LCLLQASVEE
  1741  SPTTAPSRSV THVSLVALCF DRIATQVRMN RGVVEETSNN AEPGRTSNFD RYVHATKMQP
  1801  QSSGSLRSNA GAEKGKEIAA KLNIHRVHGQ LRGLDTTDIG TCAITAIPFE KSKVLFTLEE
  1861  LDEFTFVDET DQQAVPDVTR IGPSQEKWGW IMFECGLENL TIKGGRQSGA VLYNSFGIMG
  1921  KASDTERGGV LTSNNSSDSP TGSGYNTDVS DDNLPCDRTS PSSDLNGNSV SDEQDEGVES
  1981  DDLKKDLPLM PPPPDSCSMK LTIKEIWFSF AAPTNVRSHT HAFSRQLNLL STATPAVGAW
  2041  LVPIDQLKSS LNKLETEGTL RICAVMGCIM TEALENKSVH FPLRSKYNRL TKVARFLQEN
  2101  PSCLLCNILH HYLHQANYSI IDDATMSDGL PALVTLKKGL VALARQWMKF IVVTPAFKGV
  2161  SLHRPAQPLK PQIAMDHEHE DGLGLDNGGG LQSDTSADGA EFEFDAATVS EHTMLLEGTA
  2221  NRPPPGSSGP VTGAEIMRKL SKTHTHSDSA LKIKGIHPYH SLSYTSGDTA TDSPVHVGRA
  2281  GMPVKDSPRK ESLLSYLTGS FPSLHNLLEG TPQRSSAAVK SSSLTRTGNT VATDMLSEHP
  2341  LLSEPSSVSF YNWMSNAVGN RGSVLQESPV TKSGHNSLPT GVAPNLPTIP SASDFNTVLS
  2401  SDQNTLDGTH SQHSTSQDDV AGVEEANQGF PAVQLADAQV VFKPLLSHTG IQSQDTMPFC
  2461  YRMYFGEHLS FSGTLDCLRA DIVDSDTAKE RKGKRARRQG HVNLPPLEFK PALMLGTFSI
  2521  SAVVMEKSVC TPQNSTSALS FHDLSKRYYN TFHCNFTISC QSISQHVDMA LVRLIHQFST
  2581  MIDDIKATQT DIKLSRYTAG SASPTPTFKT RKHRDFRSSD FSRSSRGSLN GGNRVNNAKN
  2641  KRTNNENNKK ESRNKNSLGR SERRTSKVSR KGSKDVVDHM TIHMDDSDSI TVSEQSEPSA
  2701  ECWQNMYKLL NFYSLISDPT GILEKSSETF GPAGVRSPTE PTCKVVFENE QDNSSLTKTQ
  2761  RKRSLVTSEP QHVTLIVFGI GMVNRTHLEA DIGGLTMESE LKRIHGSFTL KEKMKDVLHQ
  2821  KMTETCATAH IGGVNIVLLE GITPNIQLED FPTSPTSTAK QEFLTVVKCS IAKSQALYSA
  2881  QRGLKTNNAA VFKVGAISIN IPQHPATLHS MMVRSSHQLS KQISDLIRQP STAPQPVKED
  2941  IATPLPSEKT PTSVNQTPVE TNEFPQLPEG LEKKPIVLKF SAMLDGIAIG AALLPSLKAE
  3001  YKMGRMRSHG MTGAQTRFTF ELPNHRLRFT SKVSATDMST IPPSASLNLP PVTMSGKYIM
  3061  EEHDSYSDQV WSIDELPSKQ GYYLQGNYLR CVAEVGSFEH NLTTDLLNHL VFVQKVFMKE
  3121  VNEVIQKVSG GEQPIPLWNE HDGTADGDKP KILLYSLNLQ FKGIQVTATT PSMRAVRFET
  3181  GLIELELSNR LQTKASPGSS SYLKLFGKCQ VDLNLALGQI VKHQVYEEAG SDFHQVAYFK
  3241  TRIGLRNALR EEISGSSDRE AVLITLNRPI VYAQPVAFDR AVLFWLNYKA AYDNWNEQRM
  3301  ALHKDIHMAT KEVVDMLPGI QQTSAQAFGT LFLQLTVNDL GICLPITNTA QSNHTGDLDT
  3361  GSALVLTIES TLITACSSES LVSKGHFKNF CIRFADGFET SWDDWKPEIH GDLVMNACVV
  3421  PDGTYEVCSR TTGQAAAESS SAGTWTLNVL WKMCGIDVHM DPNIGKRLNA LGNTLTTLTG
  3481  EEDIDDIADL NSVNIADLSD EDEVDTMSPT IHTEATDYRR QAASASQPGE LRGRKIMKRI
  3541  VDIRELNEQA KVIDDLKKLG ASEGTINQEI QRYQQLESVA VNDIRRDVRK KLRRSSMRAA
  3601  SLKDKWGLSY KPSYSRSKSI SASGRPPLKR MERASSRVGE TEELPEIRVD AASPGPRVTF
  3661  NIQDTFPEET ELDLLSVTIE GPSHYSSNSE GSCSVFSSPK TPGGFSPGIP FQTEEGRRDD
  3721  SLSSTSEDSE KDEKDEDHER ERFYIYRKPS HTSRKKATGF AAVHQLFTER WPTTPVNRSL
  3781  SGTATERNID FELDIRVEID SGKCVLHPTT LLQEHDDISL RRSYDRSSRS LDQDSPSKKK
  3841  KFQTNYASTT HLMTGKKVPS SLQTKPSDLE TTVFYIPGVD VKLHYNSKTL KTESPNASRG
  3901  SSLPRTLSKE SKLYGMKDSA TSPPSPPLPS TVQSKTNTLL PPQPPPIPAA KGKGSGGVKT
  3961  AKLYAWVALQ SLPEEMVISP CLLDFLEKAL ETIPITPVER NYTAVSSQDE DMGHFEIPDP
  4021  MEESTTSLVS SSTSAYSSFP VDVVVYVRVQ PSQIKFSCLP VSRVECMLKL PSLDLVFSSN
  4081  RGELETLGTT YPAETLSPGG NATQSGTKTS ASKTGIPGSS GLGSPLGRSR HSSSQSDLTS
  4141  SSSSSSGLSF TACMSDFSLY VFHPYGAGKQ KTAVSGLTPG SGGLGNVDEE PTSVTGRKDS
  4201  LSINLEFVKV SLSRIRRSGG ASFFESQSVS KSASKMDTTL INISAVCDIG SASFKYDMRR
  4261  LSEILAFPRA WYRRSIARRL FLGDQTINLP TSGPGTPDSI EGVSQHLSPE SSRKAYCKTW
  4321  EQPSQSASFT HMPQSPNVFN EHMTNSTMSP GTVGQSLKSP ASIRSRSVSD SSVPRRDSLS
  4381  KTSTPFNKSN KAASQQGTPW ETLVVFAINL KQLNVQMNMS NVMGNTTWTT SGLKSQGRLS
  4441  VGSNRDREIS MSVGLGRSQL DSKGGVVGGT IDVNALEMVA HISEHPNQQP SHKIQITMGS
  4501  TEARVDYMGS SILMGIFSNA DLKLQDEWKV NLYNTLDSSI TDKSEIFVHG DLKWDIFQVM
  4561  ISRSTTPDLI KIGMKLQEFF TQQFDTSKRA LSTWGPVPYL PPKTMTSNLE KSSQEQLLDA
  4621  AHHRHWPGVL KVVSGCHISL FQIPLPEDGM QFGGSMSLHG NHMTLACFHG PNFRSKSWAL
  4681  FHLEEPNIAF WTEAQKIWED GSSDHSTYIV QTLDFHLGHN TMVTKPCGAL ESPMATITKI
  4741  TRRRHENPPH GVASVKEWFN YVTATRNEEL NLLRNVDANN TENSTTVKNS SLLSGFRGGS
  4801  SYNHETETIF ALPRMQLDFK SIHVQEPQEP SLQDASLKPK VECSVVTEFT DHICVTMDAE
  4861  LIMFLHDLVS AYLKEKEKAI FPPRILSTRP GQKSPIIIHD DNSSDKDRED SITYTTVDWR
  4921  DFMCNTWHLE PTLRLISWTG RKIDPVGVDY ILQKLGFHHA RTTIPKWLQR GVMDPLDKVL
  4981  SVLIKKLGTA LQDEKEKKGK DKEEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLTP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • retina: 58 nTPM
  • parathyroid gland: 40 nTPM
  • skeletal muscle: 39 nTPM
  • bone marrow: 37 nTPM
  • choroid plexus: 32 nTPM
  • tongue: 32 nTPM

Single-cell type

  • neutrophil progenitors: 838 nCPM
  • thyrotrophs: 530 nCPM
  • neutrophils: 520 nCPM
  • gonadotrophs: 455 nCPM
  • pituicytes/fscs: 445 nCPM
  • lactotrophs: 435 nCPM

Immune cell

  • eosinophil: 1.9 nTPM
  • intermediate monocyte: 0.8 nTPM
  • naive B-cell: 0.8 nTPM
  • neutrophil: 0.7 nTPM
  • MAIT T-cell: 0.5 nTPM
  • basophil: 0.3 nTPM

Brain region

  • choroid plexus: 87 nTPM
  • medulla oblongata: 72 nTPM
  • white matter: 72 nTPM
  • cerebral cortex: 67 nTPM
  • midbrain: 66 nTPM
  • thalamus: 66 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BLTP1.

Disease | AllUniProt

Conditions BLTP1 is implicated in, by any mechanism.

Disease | GeneticClinVar

55 pathogenic / likely-pathogenic of 869 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Bridge-like lipid transfer protein family member 1
  • Bridge-like lipid transfer protein family member 1, N-terminal
  • Bridge-like lipid transfer protein family member 1, middle region
  • Bridge-like lipid transfer protein family member 1, C-terminal
  • BLTP1-like family N-terminal region
  • BLTP1-like family middle region
  • BLTP1-like family C-terminal region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BLTP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • LTAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLTP1 as an antibody target. Whether an autoantibody or antibody against BLTP1 could matter depends on whether native BLTP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLTP1 is annotated at the cell surface, where native BLTP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BLTP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BLTP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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