Seroatlas · Human Serome Atlas

BLID

BH3-like motif-containing cell death inducer

Also known as: BLID_HUMAN, BRCC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZY5
Gene
BLID
Ensembl
ENSG00000259571
Chromosome
11
Canonical length
108 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q8IZY5|BLID
     1  MVTLLPIEGQ EIHFFEILES ECVLYTGWIE RASGSSIYPE AKARLPLEAL LGSNKEPMLP
    61  KETVLSLKRY NLGSSAMKRN VPGHVLQRPS YLTRIQVTLL CNSSAEAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLID can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 0.2 nTPM
  • choroid plexus: 0.2 nTPM
  • heart muscle: 0.1 nTPM
  • ovary: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • proximal tubule cells: 1.2 nCPM
  • podocytes: 0.3 nCPM
  • renal collecting duct intercalated cells: 0.2 nCPM
  • fibroblasts: 0.1 nCPM
  • loop of henle epithelial cells: 0.1 nCPM
  • renal collecting duct principal cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 15 nTPM
  • medulla oblongata: 11 nTPM
  • basal ganglia: 10 nTPM
  • thalamus: 10 nTPM
  • pons: 8.5 nTPM
  • hypothalamus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.4
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLID as an antibody target. Whether an autoantibody or antibody against BLID could matter depends on whether native BLID is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLID is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BLID as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BLID. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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