BLCAP

Protein identityUniProt · HPA

UniProt accession

P62952

Gene

BLCAP

Ensembl

ENSG00000166619

Chromosome

20

Canonical length

87 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli

OverviewNCBI Gene

This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P62952|BLCAP
     1  MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS
    61  CWGNCFLYHC SDSPLPESAH DPGVVGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLCAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

452 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0.51

gnomAD missense Z

1.03

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic nuclear changes

Cellular components

• cytoplasm
• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Apoptosis inducing factor BLCAP
• Bladder cancer-related protein BC10

KeywordsUniProt

• Apoptosis
• Cell cycle
• Cytoplasm
• Membrane
• Nucleus
• RNA editing
• Transmembrane
• Transmembrane helix
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of BLCAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RB1
• STAT3