BLACE
B-cell acute lymphoblastic leukemia-expressed protein
Also known as: BLACE_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for BLACE in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>A4D250|BLACE
1 MMKDIIPASS WASEESTDLQ NGSFPLSVAP RSEFPRRRAL EDWLLSVFLA DQAESEGQLV
61 LERVRDTPPP VTSPRGDGIC VSRGKAPSSP GGSTHAWLYL TRHFPWSPFP HGGWTDTSEP
121 CVLETLGGSS LAALRGNSLW VQSSGACAFC VYESLIEQSL PNERFEELLL GPSPGEVMKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BLACE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.57
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BLACE as an antibody target. Whether an autoantibody or antibody against BLACE could matter depends on whether native BLACE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BLACE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BLACE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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