Seroatlas · Human Serome Atlas

BIVM

Basic immunoglobulin-like variable motif-containing protein

Also known as: BIVM_HUMAN, FLJ20159

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UB2
Gene: BIVM
Ensembl: ENSG00000134897
Chromosome: 13
Canonical length: 503 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA endonuclease activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q86UB2|BIVM
     1  MPNVAETERS NDSGNGEHKS ERKSPEENLQ GAVKSFCTSA SGAPLGPKGD GHYPWSCPVT
    61  HTREKIYAIC SDYAFLNQAT SIYKTPNPSR SPCLPDSTSL SAGNNSSRYI GIPTSTSEII
   121  YNEENSLENL SNSLGKLPLA WEIDKSEFDG VTTNSKHKSG NAKKQVSKRK TSDKKGRYQK
   181  ECPQHSPLED IKQRKVLDLR RWYCISRPQY KTSCGISSLI SCWNFLYSTM GAGNLPPITQ
   241  EEALHILGFQ PPFEDIRFGP FTGNTTLMRW FRQINDHFHV KGCSYVLYKP HGKNKTAGET
   301  ASGALSKLTR GLKDESLAYI YHCQNHYFCP IGFEATPVKA NKAFSRGPLS PQEVEYWILI
   361  GESSRKHPAI HCKKWADIVT DLNTQNPEYL DIRHLERGLQ YRKTKKVGGN LHCIIAFQRL
   421  NWQRFGLWNF PFGTIRQESQ PPTHAQGIAK SESEDNISKK QHGRLGRSFS ASFHQDSAWK
   481  KMSSIHERRN SGYQGYSDYD GND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIVM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 20 nTPM
heart muscle: 18 nTPM
liver: 18 nTPM
tongue: 18 nTPM
skeletal muscle: 17 nTPM
kidney: 15 nTPM

Single-cell type

brain inhibitory neurons: 96 nCPM
brain excitatory neurons: 85 nCPM
oligodendrocyte progenitor cells: 81 nCPM
oligodendrocytes: 69 nCPM
other brain neurons: 66 nCPM
choroid plexus epithelial cells: 61 nCPM

Immune cell

NK-cell: 7.7 nTPM
basophil: 5.5 nTPM
MAIT T-cell: 5.2 nTPM
memory CD8 T-cell: 2.9 nTPM
gdT-cell: 2.2 nTPM
myeloid DC: 1.7 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 14 nTPM
white matter: 13 nTPM
thalamus: 13 nTPM
amygdala: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIVM as an antibody target. Whether an autoantibody or antibody against BIVM could matter depends on whether native BIVM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIVM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIVM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...