Seroatlas · Human Serome Atlas

BIRC8

Baculoviral IAP repeat-containing protein 8

Also known as: BIRC8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P09
Gene: BIRC8
Canonical length: 236 aa

OverviewNCBI Gene

No narrative summary is available for BIRC8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q96P09|BIRC8
     1  MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK PKEDPWEQHA
    61  KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS LTKRISDTIF PNPMLQEAIR
   121  MGFDFKDVKK IMEERIQTSG SNYKTLEVLV ADLVSAQKDT TENELNQTSL QREISPEEPL
   181  RRLQEEKLCK ICMDRHIAVV FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIRC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.01

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIRC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

XAF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIRC8 as an antibody target. Whether an autoantibody or antibody against BIRC8 could matter depends on whether native BIRC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIRC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIRC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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