Seroatlas · Human Serome Atlas

BICRAL

BRD4-interacting chromatin-remodeling complex-associated protein-like

Also known as: BICRL_HUMAN, GLTSCR1L, KIAA0240, SMARCK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6AI39
Gene: BICRAL
Ensembl: ENSG00000112624
Chromosome: 6
Canonical length: 1079 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of DNA-templated transcription. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1079 residues, UniProt reviewed canonical sequence.

>Q6AI39|BICRAL
     1  MDDDDDSCLL DLIGDPQALN YFLHGPSNKS SNDDLTNAGY SAANSNSIFA NSSNADPKSS
    61  LKGVSNQLGE GPSDGLPLSS SLQFLEDELE SSPLPDLTED QPFDILQKSL QEANITEQTL
   121  AEEAYLDASI GSSQQFAQAQ LHPSSSASFT QASNVSNYSG QTLQPIGVTH VPVGASFASN
   181  TVGVQHGFMQ HVGISVPSQH LSNSSQISGS GQIQLIGSFG NHPSMMTINN LDGSQIILKG
   241  SGQQAPSNVS GGLLVHRQTP NGNSLFGNSS SSPVAQPVTV PFNSTNFQTS LPVHNIIIQR
   301  GLAPNSNKVP INIQPKPIQM GQQNTYNVNN LGIQQHHVQQ GISFASASSP QGSVVGPHMS
   361  VNIVNQQNTR KPVTSQAVSS TGGSIVIHSP MGQPHAPQSQ FLIPTSLSVS SNSVHHVQTI
   421  NGQLLQTQPS QLISGQVASE HVMLNRNSSN MLRTNQPYTG PMLNNQNTAV HLVSGQTFAA
   481  SGSPVIANHA SPQLVGGQMP LQQASPTVLH LSPGQSSVSQ GRPGFATMPS VTSMSGPSRF
   541  PAVSSASTAH PSLGSAVQSG SSGSNFTGDQ LTQPNRTPVP VSVSHRLPVS SSKSTSTFSN
   601  TPGTGTQQQF FCQAQKKCLN QTSPISAPKT TDGLRQAQIP GLLSTTLPGQ DSGSKVISAS
   661  LGTAQPQQEK VVGSSPGHPA VQVESHSGGQ KRPAAKQLTK GAFILQQLQR DQAHTVTPDK
   721  SHFRSLSDAV QRLLSYHVCQ GSMPTEEDLR KVDNEFETVA TQLLKRTQAM LNKYRCLLLE
   781  DAMRINPSAE MVMIDRMFNQ EERASLSRDK RLALVDPEGF QADFCCSFKL DKAAHETQFG
   841  RSDQHGSKAS SSLQPPAKAQ GRDRAKTGVT EPMNHDQFHL VPNHIVVSAE GNISKKTECL
   901  GRALKFDKVG LVQYQSTSEE KASRREPLKA SQCSPGPEGH RKTSSRSDHG TESKLSSILA
   961  DSHLEMTCNN SFQDKSLRNS PKNEVLHTDI MKGSGEPQPD LQLTKSLETT FKNILELKKA
  1021  GRQPQSDPTV SGSVELDFPN FSPMASQENC LEKFIPDHSE GVVETDSILE AAVNSILEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BICRAL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
cerebellum: 13 nTPM
ovary: 12 nTPM
lymph node: 12 nTPM
tonsil: 12 nTPM
thymus: 11 nTPM

Single-cell type

myonuclei: 359 nCPM
neutrophils: 345 nCPM
corticotrophs: 235 nCPM
fibro-adipogenic progenitors: 210 nCPM
thyrotrophs: 201 nCPM
innate lymphoid cells: 195 nCPM

Immune cell

neutrophil: 3.8 nTPM
eosinophil: 2.8 nTPM
basophil: 2.3 nTPM
gdT-cell: 2.2 nTPM
memory CD8 T-cell: 2.2 nTPM
MAIT T-cell: 1.9 nTPM

Brain region

cerebellum: 46 nTPM
white matter: 28 nTPM
cerebral cortex: 25 nTPM
pons: 24 nTPM
hypothalamus: 24 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.07
gnomAD pLI: 1
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BICRAL as an antibody target. Whether an autoantibody or antibody against BICRAL could matter depends on whether native BICRAL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BICRAL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BICRAL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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