Seroatlas · Human Serome Atlas

BHLHA15

Class A basic helix-loop-helix protein 15

Also known as: BHA15_HUMAN, BHLHB8, MIST1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTS1
Gene: BHLHA15
Ensembl: ENSG00000180535
Chromosome: 7
Canonical length: 189 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Predicted to act upstream of or within several processes, including cell-cell adhesion mediated by cadherin; epithelial cell maturation; and intracellular distribution of mitochondria. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q7RTS1|BHLHA15
     1  MKTKNRPPRR RAPVQDTEAT PGEGTPDGSL PNPGPEPAKG LRSRPARAAA RAPGEGRRRR
    61  PGPSGPGGRR DSSIQRRLES NERERQRMHK LNNAFQALRE VIPHVRADKK LSKIETLTLA
   121  KNYIKSLTAT ILTMSSSRLP GLEGPGPKLY QHYQQQQQVA GGALGATEAQ PQGHLQRYST
   181  QIHSFREGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BHLHA15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 527 nTPM

Expression across tissuesHPA

Tissue

pancreas: 527 nTPM
salivary gland: 137 nTPM
stomach: 49 nTPM
prostate: 12 nTPM
liver: 10 nTPM
spleen: 8.3 nTPM

Single-cell type

pancreatic acinar cells: 151 nCPM
plasma cells: 52 nCPM
salivary acinar cells: 47 nCPM
breast lactating cells: 44 nCPM
gastric chief cells: 33 nCPM
lacrimal acinar cells: 22 nCPM

Immune cell

memory B-cell: 0.5 nTPM
plasmacytoid DC: 0.3 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 5 nTPM
hypothalamus: 3.8 nTPM
hippocampal formation: 3.6 nTPM
spinal cord: 2.9 nTPM
basal ganglia: 2.6 nTPM
amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.01
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BHLHA15 as an antibody target. Whether an autoantibody or antibody against BHLHA15 could matter depends on whether native BHLHA15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BHLHA15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BHLHA15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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