Seroatlas · Human Serome Atlas

BEND7

BEN domain-containing protein 7

Also known as: BEND7_HUMAN, C10orf30, FLJ40283

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7W2
Gene: BEND7
Ensembl: ENSG00000165626
Chromosome: 10
Canonical length: 413 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q8N7W2|BEND7
     1  MEFSERKRSR KSQSFKLVSR DYHHEVYKIP EFSNDVNGEA KETQPIFLGD ESMEIKKQIT
    61  GMRRLLNDST GRIYQRVGKE GEKLKEEPQD LDLVWPPRLN SSAEAPQSLH PSSRGVWNEL
   121  PPQSGQFSGQ YGTRSRTFQS QPHPTTSSNG ELPVVNSSAG SNCCTCNCQS TLQAILQELK
   181  TMRKLMQIQA VGTQNRQQPP ISLICSQRTA VSRKRNKKKK VPPKTVEPLT VKQKPSGSEM
   241  EKKSVVASEL SALQAAEHTS PEESRVLGFG IVLESPSSDP EVQLAEGFDV FMPKSQLDSI
   301  LSNYTRSGSL LFRKLVCAFF DDKTLANSLP NGKRKRGLND NRKGLDQNIV GAIKVFTEKY
   361  CTANHVDKLP GPRDWVQILQ DQIKLARRRL KRGSEIADSD ERLDGIALPP TVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEND7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 23 nTPM
small intestine: 21 nTPM
kidney: 20 nTPM
duodenum: 17 nTPM
parathyroid gland: 16 nTPM
retina: 15 nTPM

Single-cell type

late spermatids: 512 nCPM
early spermatids: 255 nCPM
epididymal efferent duct absorptive cells: 231 nCPM
pituitary stem cells: 230 nCPM
epididymal efferent duct ciliated cells: 171 nCPM
corticotrophs: 152 nCPM

Immune cell

neutrophil: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 10 nTPM
cerebellum: 10 nTPM
choroid plexus: 9.9 nTPM
midbrain: 8.7 nTPM
thalamus: 7.6 nTPM
medulla oblongata: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.01
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

BEN domain
BEN domain
BEN domain-containing protein 7

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEND7 as an antibody target. Whether an autoantibody or antibody against BEND7 could matter depends on whether native BEND7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEND7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEND7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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