Seroatlas · Human Serome Atlas

BEND6

BEN domain-containing protein 6

Also known as: bA203B9.1, BEND6_HUMAN, C6orf65, FLJ30162

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SZJ8
Gene: BEND6
Ensembl: ENSG00000151917
Chromosome: 6
Canonical length: 279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables transcription corepressor activity. Predicted to be involved in negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q5SZJ8|BEND6
     1  MQKIVQTDEI TNTQAFRKGK RKRTETMDSE NANSDMDKGQ RDPYSGNAFL PGESSSEDEE
    61  PLAELSKEEL CAKIKSLKEK LTNTRKENSR LRQSLVMLQV LPQAVTQFEE LVGMAEALLK
   121  GGGTMSTSAS TLWRATNNSS PDSFASTCSN SNSNSSSPVS LKPEEEHQTD EKQFQIEKWQ
   181  IARCNKSKPQ KFINDLMQVL YTNEYMATHS LTGAKSSTSR DKAVKPAMNQ NEVQEIIGVT
   241  KQLFPNTDDV SIRRMIGQKL NNCTKKPNLS KNLNSQDIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEND6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 45 nTPM
cerebral cortex: 30 nTPM
amygdala: 18 nTPM
hippocampal formation: 17 nTPM
midbrain: 17 nTPM
basal ganglia: 16 nTPM

Single-cell type

retinal bipolar cells: 157 nCPM
brain excitatory neurons: 134 nCPM
brain inhibitory neurons: 106 nCPM
retinal amacrine cells: 80 nCPM
other brain neurons: 78 nCPM
retinal ganglion cells: 73 nCPM

Immune cell

plasmacytoid DC: 8.8 nTPM
myeloid DC: 1.8 nTPM
NK-cell: 1.5 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 73 nTPM
cerebellum: 72 nTPM
white matter: 54 nTPM
pons: 52 nTPM
medulla oblongata: 49 nTPM
hypothalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

BEN domain
BEN domain
BEN domain-containing protein 6-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEND6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RBPJ

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEND6 as an antibody target. Whether an autoantibody or antibody against BEND6 could matter depends on whether native BEND6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEND6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEND6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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