Seroatlas · Human Serome Atlas

BEND4

BEN domain-containing protein 4

Also known as: BEND4_HUMAN, CCDC4, FLJ35632, FLJ43965

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU67
Gene: BEND4
Ensembl: ENSG00000188848
Chromosome: 4
Canonical length: 534 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q6ZU67|BEND4
     1  MEEEMQPAEE GPSVPKIYKQ RSPYSVLKTF PSKRPALAKR YERPTLVELP HVRAPPPPPP
    61  PFAPHAAVSI SSSEPPPQQF QAQSSYPPGP GRAAAAASSS SPSCTPATSQ GHLRTPAQPP
   121  PASPAASSSS SFAAVVRYGP GAAAAAGTGG TGSDSASLEL SAESRMILDA FAQQCSRVLS
   181  LLNCGGKLLD SNHSQSMISC VKQEGSSYNE RQEHCHIGKG VHSQTSDNVD IEMQYMQRKQ
   241  QTSAFLRVFT DSLQNYLLSG SFPTPNPSSA SEYGHLADVD PLSTSPVHTL GGWTSPATSE
   301  SHGHPSSSTL PEEEEEEDEE GYCPRCQELE QEVISLQQEN EELRRKLESI PVPCQTVLDY
   361  LKMVLQHHNQ LLIPQPADQP TEGSKQLLNN YPVYITSKQW DEAVNSSKKD GRRLLRYLIR
   421  FVFTTDELKY SCGLGKRKRS VQSGETGPER RPLDPVKVTC LREFIRMHCT SNPDWWMPSE
   481  EQINKVFSDA VGHARQGRAV GTFLHNGGSF YEGIDHQASQ DEVFNKSSQD GSGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEND4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

testis: 8.8 nTPM
prostate: 2.9 nTPM
lymph node: 1.6 nTPM
tonsil: 1.3 nTPM
small intestine: 1.1 nTPM
spleen: 1.1 nTPM

Single-cell type

undifferentiated spermatogonia: 71 nCPM
differentiating spermatogonia: 48 nCPM
müller glia: 32 nCPM
prostatic glandular cells: 24 nCPM
hematopoietic stem cells: 19 nCPM
lactotrophs: 18 nCPM

Immune cell

naive B-cell: 0.3 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 7.4 nTPM
pons: 5.8 nTPM
cerebral cortex: 3 nTPM
hippocampal formation: 2.8 nTPM
hypothalamus: 2.6 nTPM
medulla oblongata: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.98
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Protein domainsUniProt · Pfam · InterPro

BEN domain
BEN domain
BEN domain-containing protein 4

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEND4 as an antibody target. Whether an autoantibody or antibody against BEND4 could matter depends on whether native BEND4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEND4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEND4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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