Seroatlas · Human Serome Atlas

BEND2

BEN domain-containing protein 2

Also known as: BEND2_HUMAN, CXorf20, MGC33653

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDZ0
Gene: BEND2
Ensembl: ENSG00000177324
Chromosome: X
Canonical length: 799 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

799 residues, UniProt reviewed canonical sequence.

>Q8NDZ0|BEND2
     1  MSERTQEQDF VIITVDDSDD NNDCSIEMVE VSETADNSTN DIADDSTYVT ADNPTDDTAT
    61  QPNFPGGNDG HHRPLQMSYG SGSVTQAGVQ WHDHSSLQPQ PLGLKQFFHL SLPSSWDDRR
   121  TPPCPVAHGD QIVSQINHPV HLRRYSYNSE EVDFPKRGRF YTPEVQSSIS PPAERQETHA
   181  WASPAVTSLE SAACHELQEA DLSESLSYPR IVSSSSLQQY VAQGGSFPCF GMPWNFISGG
   241  AESTNAVISF ANATTAVPMA VLSRRESSLA NNPGVVNYSA LPENENVGPG RALSSFCFHP
   301  NLEMPERPAN SSKNSTETAN YPTLMGNYNG QNTASLSVFI PPYFAEKIIL TEMPGTTETN
   361  VENNSQTVYY PALSGNTSAP YPASSYLPIT SNFESGPQMS YGTMSYSTEM KNNCDQDDAS
   421  ASACLTPDFA LLPLNILVKV DTNTENSVNT MNRSTLLDSD SGQDSSSSSV CIPPKYGYLG
   481  DPKRNVRVLK IHLLAVQNMA KPKQAACYLV RILFSKEILI SSSVDIHLKD SQSLDPNKMA
   541  ALREYLATTF PTCDLHEHGK DWQDCISGIN SMIYCLCSEG KSTPKTVRKN KKRTNRVASA
   601  SADRNDQRGR DGGEGCSWMF QPMNNSKMRE KRNLQPNSNA IPEGMREPST DNPEEPGEAW
   661  SYFGRPWRNI RMPCSVLTLA KTKSCASLSA RYLIQKLFTK DVLVQSNVYG NLKHGLCALD
   721  PNKISALREF LQENYPICDL SENGRDWKSC VTSINSGIRS LRHDVRRAEA RSQSLPAVTP
   781  PELEQESKPG DPDATDPST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEND2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 5 nTPM

Expression across tissuesHPA

Tissue

testis: 5 nTPM
bone marrow: 0.2 nTPM
spleen: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

platelets: 314 nCPM
early primary spermatocytes: 125 nCPM
megakaryocytes: 25 nCPM
peritubular myoid cells: 22 nCPM
leydig cells: 21 nCPM
thymic myoid cells: 16 nCPM

Immune cell

basophil: 2.5 nTPM
total PBMC: 1.8 nTPM
neutrophil: 0.6 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 1.1 nTPM
cerebellum: 1 nTPM
cerebral cortex: 1 nTPM
pons: 1 nTPM
thalamus: 1 nTPM
choroid plexus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.09
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEND2 as an antibody target. Whether an autoantibody or antibody against BEND2 could matter depends on whether native BEND2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEND2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEND2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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