Seroatlas · Human Serome Atlas

BDKRB1

B1 bradykinin receptor

Also known as: B1BKR, BKR1, BKRB1_HUMAN, bradyb1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46663
Gene: BDKRB1
Ensembl: ENSG00000100739
Chromosome: 14
Canonical length: 353 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>P46663|BDKRB1
     1  MASSWPPLEL QSSNQSQLFP QNATACDNAP EAWDLLHRVL PTFIISICFF GLLGNLFVLL
    61  VFLLPRRQLN VAEIYLANLA ASDLVFVLGL PFWAENIWNQ FNWPFGALLC RVINGVIKAN
   121  LFISIFLVVA ISQDRYRVLV HPMASRRQQR RRQARVTCVL IWVVGGLLSI PTFLLRSIQA
   181  VPDLNITACI LLLPHEAWHF ARIVELNILG FLLPLAAIVF FNYHILASLR TREEVSRTRC
   241  GGRKDSKTTA LILTLVVAFL VCWAPYHFFA FLEFLFQVQA VRGCFWEDFI DLGLQLANFF
   301  AFTNSSLNPV IYVFVGRLFR TKVWELYKQC TPKSLAPISS SHRKEIFQLF WRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BDKRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 22 nTPM
esophagus: 13 nTPM
gallbladder: 13 nTPM
adipose tissue: 10 nTPM
vagina: 7.5 nTPM
kidney: 6.8 nTPM

Single-cell type

esophageal apical cells: 94 nCPM
basal keratinocytes: 37 nCPM
esophageal suprabasal cells: 25 nCPM
fibroblasts: 23 nCPM
epicardial cells: 23 nCPM
esophageal basal cells: 19 nCPM

Immune cell

T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2.2 nTPM
cerebral cortex: 1 nTPM
white matter: 0.8 nTPM
pons: 0.5 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BDKRB1 as an antibody target. Whether an autoantibody or antibody against BDKRB1 could matter depends on whether native BDKRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BDKRB1 is annotated at the cell surface, where native BDKRB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BDKRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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