BCO2

Protein identityUniProt · HPA

UniProt accession

Q9BYV7

Gene

BCO2

Ensembl

ENSG00000197580

Chromosome

11

Canonical length

579 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q9BYV7|BCO2
     1  MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG LPCVAPLLTT
    61  VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDKYN HWFDGMALLH QFRMAKGTVT
   121  YRSKFLQSDT YKANSAKNRI VISEFGTLAL PDPCKNVFER FMSRFELPGK AAAMTDNTNV
   181  NYVRYKGDYY LCTETNFMNK VDIETLEKTE KVDWSKFIAV NGATAHPHYD LDGTAYNMGN
   241  SFGPYGFSYK VIRVPPEKVD LGETIHGVQV ICSIASTEKG KPSYYHSFGM TRNYIIFIEQ
   301  PLKMNLWKIA TSKIRGKAFS DGISWEPQCN TRFHVVEKRT GQLLPGRYYS KPFVTFHQIN
   361  AFEDQGCVII DLCCQDNGRT LEVYQLQNLR KAGEGLDQVH NSAAKSFPRR FVLPLNVSLN
   421  APEGDNLSPL SYTSASAVKQ ADGTIWCSHE NLHQEDLEKE GGIEFPQIYY DRFSGKKYHF
   481  FYGCGFRHLV GDSLIKVDVV NKTLKVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP
   541  NQNESNFILV LDAKNFEELG RAEVPVQMPY GFHGTFIPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

52 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

0.41

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carotene catabolic process
• regulation of mitochondrial membrane potential
• regulation of reactive oxygen species metabolic process
• retinal metabolic process
• retinoic acid metabolic process
• carotene metabolic process
• carotenoid metabolic process
• lutein catabolic process
• lycopene catabolic process
• xanthophyll catabolic process
• zeaxanthin catabolic process

Molecular functions

• beta-carotene 15,15'-dioxygenase activity
• carotenoid dioxygenase activity
• metal ion binding
• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
• beta,beta-carotene-9',10'-cleaving oxygenase activity

Cellular components

• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Carotenoid oxygenase
• Retinal pigment epithelial membrane protein

KeywordsUniProt

• Dioxygenase
• Iron
• Lipid metabolism
• Metal-binding
• Mitochondrion
• Oxidoreductase