Seroatlas · Human Serome Atlas

BCLAF3

BCLAF1 and THRAP3 family member 3

Also known as: BCLA3_HUMAN, CXorf23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2AJT9
Gene
BCLAF3
Ensembl
ENSG00000173681
Chromosome
X
Canonical length
711 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and transcription coregulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be part of mediator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>A2AJT9|BCLAF3
     1  MARSRSRSPR WKHRSLSPVP RNAEHYKQRH SHGHYGCEYR KDPKRPVAWR MDSEKHGQSK
    61  PRIPSRGNIY YQSYEHRSPS PNIRNSLENV YMYKPHRGYS PGRGDSNRRA QYMPKYSEGI
   121  PYKEHERNSY PQKVQGGHSP DDHRVRGSGK GGKPPQRSIA DSFRFEGKWH EDELRHQRIQ
   181  EEKYSQSTRR GSEDFETRSS FQKRYPEDRD FRKYGHTSKR PKDVERYESR EPARNPKWKP
   241  EHSLPPYQED TDQWNLGPQT YRHAEREHPE TSSATKVSYD YRHKRPKLLD GDQDFSDGRT
   301  QKYCKEEDRK YSFQKGPLNR ELDCFNTGRG RETQDGQVKE PFKPSKKDSI ACTYSNKNDV
   361  DLRSSNDKWK EKIKKEGDCR KESNSSSNQL DKSQKLPDVK PSPINLRKKS LTVKVDVKKT
   421  VDTFRVASSY STERQMSHDL VAVGRKSENF HPVFEHLDST QNTENKPTGE FAQEIITIIH
   481  QVKANYFPSP GITLHERFST MQDIHKADVN EIPLNSDPEI HRRIDMSLAE LQSKQAVIYE
   541  SEQTLIKIID PNDLRHDIER RRKERLQNED EHIFHIASAA ERDDQNSSFS KVKNVHTDGF
   601  QKPTHFIKSN FRKCIEKPYM NYTTQRKDII THKPFEVEGN HRNTRVRPFK SNFRGGRCQP
   661  NYKSGLVQKS LYIQAKYQRL RFTGPRGFIT HKFRERLMRK KKEYTDVATG I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCLAF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 6.7 nTPM
  • cerebellum: 6.2 nTPM
  • retina: 5.2 nTPM
  • skin: 5.1 nTPM
  • endometrium: 4.3 nTPM
  • blood vessel: 4.2 nTPM

Single-cell type

  • neutrophils: 142 nCPM
  • pituicytes/fscs: 105 nCPM
  • myonuclei: 98 nCPM
  • distal convoluted tubule cells: 79 nCPM
  • adipocytes: 78 nCPM
  • bergmann glia: 78 nCPM

Immune cell

  • basophil: 1.4 nTPM
  • neutrophil: 1.2 nTPM
  • naive B-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • gdT-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • cerebellum: 27 nTPM
  • cerebral cortex: 19 nTPM
  • white matter: 18 nTPM
  • thalamus: 18 nTPM
  • hippocampal formation: 18 nTPM
  • medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.63
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCLAF3 as an antibody target. Whether an autoantibody or antibody against BCLAF3 could matter depends on whether native BCLAF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCLAF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCLAF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCLAF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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