Seroatlas · Human Serome Atlas

BCL7C

B-cell CLL/lymphoma 7 protein family member C

Also known as: BCL7C_HUMAN, SMARCJ3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUZ0
Gene: BCL7C
Ensembl: ENSG00000099385
Chromosome: 16
Canonical length: 217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q8WUZ0|BCL7C
     1  MAGRTVRAET RSRAKDDIKK VMATIEKVRR WEKRWVTVGD TSLRIFKWVP VVDPQEEERR
    61  RAGGGAERSR GRERRGRGAS PRGGGPLILL DLNDENSNQS FHSEGSLQKG TEPSPGGTPQ
   121  PSRPVSPAGP PEGVPEEAQP PRLGQERDPG GITAGSTDEP PMLTKEEPVP ELLEAEAPEA
   181  YPVFEPVPPV PEAAQGDTED SEGAPPLKRI CPNAPDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL7C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

kidney: 85 nTPM
blood vessel: 71 nTPM
cervix: 66 nTPM
ovary: 65 nTPM
colon: 64 nTPM
skin: 62 nTPM

Single-cell type

lymphatic endothelial cells: 135 nCPM
breast myoepithelial cells: 111 nCPM
esophageal basal cells: 105 nCPM
hepatic stellate cells: 103 nCPM
fallopian secretory cells: 85 nCPM
enteric transient amplifying cells: 84 nCPM

Immune cell

memory CD8 T-cell: 9.5 nTPM
memory B-cell: 9.1 nTPM
MAIT T-cell: 8.8 nTPM
basophil: 8.2 nTPM
eosinophil: 8 nTPM
gdT-cell: 7.8 nTPM

Brain region

medulla oblongata: 56 nTPM
pons: 56 nTPM
midbrain: 53 nTPM
thalamus: 51 nTPM
basal ganglia: 50 nTPM
spinal cord: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.08
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL7C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL7C as an antibody target. Whether an autoantibody or antibody against BCL7C could matter depends on whether native BCL7C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL7C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL7C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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