BCL2L15
Bcl-2-like protein 15
Also known as: B2L15_HUMAN, Bfk, C1orf178, FLJ22588
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TBC7
- Gene
- BCL2L15
- Ensembl
- ENSG00000188761
- Chromosome
- 1
- Canonical length
- 163 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to be involved in apoptotic process and regulation of apoptotic process. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>Q5TBC7|BCL2L15
1 MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV AIIAGRLRML
61 GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC AQDSSLAYER AFLAVSVKLL
121 EYMAHIAPEV VGQVAIPMTG MINGNQAIRE FIQGQGGWEN LESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BCL2L15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 41 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 41 nTPM
- small intestine: 39 nTPM
- colon: 30 nTPM
- rectum: 25 nTPM
- stomach: 17 nTPM
- bone marrow: 13 nTPM
Single-cell type
- enterocytes: 145 nCPM
- gastric progenitor cells: 123 nCPM
- colonocytes: 92 nCPM
- neutrophil progenitors: 75 nCPM
- enteric transient amplifying cells: 67 nCPM
- endometrial secretory cells: 61 nCPM
Immune cell
- neutrophil: 0.4 nTPM
- memory CD4 T-cell: 0.2 nTPM
- MAIT T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 5.9 nTPM
- pons: 3.8 nTPM
- cerebral cortex: 3.5 nTPM
- hippocampal formation: 3.2 nTPM
- basal ganglia: 3.1 nTPM
- hypothalamus: 3.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.25
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Bcl-2-like superfamily
- Bcl-2-like protein 15
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BCL2L15 as an antibody target. Whether an autoantibody or antibody against BCL2L15 could matter depends on whether native BCL2L15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BCL2L15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BCL2L15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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