BCL2L12

Protein identityUniProt · HPA

UniProt accession

Q9HB09

Gene

BCL2L12

Ensembl

ENSG00000126453

Chromosome

19

Canonical length

250 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q9HB09|BCL2L12
     1  MAGSEELGLR EDTLRVLAAF LRRGEAAGSP VPTPPRSPAQ EEPTDFLSRL RRCLPCSLGR
    61  GAAPSESPRP CSLPIRPCYG LEPGPATPDF YALVAQRLEQ LVQEQLKSPP SPELQGPPST
   121  EKEAILRRLV ALLEEEAEVI NQKLASDPAL RSKLVRLSSD SFARLVELFC SRDDSSRPSR
   181  ACPGPPPPSP EPLARLALAM ELSRRVAGLG GTLAGLSVEH VHSFTPWIQA HGGWEGILAV
   241  SPVDLNLPLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.38

gnomAD pLI

0

gnomAD missense Z

0.14

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• negative regulation of apoptotic process
• negative regulation of cellular senescence
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• positive regulation of transcription by RNA polymerase II

Molecular functions

• p53 binding

Cellular components

• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Bcl-2-like superfamily

KeywordsUniProt

• Apoptosis
• Methylation
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of BCL2L12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BAX