BCDIN3D

Protein identityUniProt · HPA

UniProt accession

Q7Z5W3

Gene

BCDIN3D

Ensembl

ENSG00000186666

Chromosome

12

Canonical length

292 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q7Z5W3|BCDIN3D
     1  MAVPTELDGG SVKETAAEEE SRVLAPGAAP FGNFPHYSRF HPPEQRLRLL PPELLRQLFP
    61  ESPENGPILG LDVGCNSGDL SVALYKHFLS LPDGETCSDA SREFRLLCCD IDPVLVKRAE
   121  KECPFPDALT FITLDFMNQR TRKVLLSSFL SQFGRSVFDI GFCMSITMWI HLNHGDHGLW
   181  EFLAHLSSLC HYLLVEPQPW KCYRAAARRL RKLGLHDFDH FHSLAIRGDM PNQIVQILTQ
   241  DHGMELICCF GNTSWDRSLL LFRAKQTIET HPIPESLIEK GKEKNRLSFQ KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCDIN3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0

gnomAD missense Z

0.23

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• miRNA metabolic process
• negative regulation of pre-miRNA processing
• pre-miRNA processing
• RNA methylation
• tRNA methylation

Molecular functions

• O-methyltransferase activity
• pre-miRNA binding
• RNA methyltransferase activity
• small RNA 2'-O-methyltransferase activity
• tRNA methyltransferase activity

Cellular components

• cytoplasm
• cytosol
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• RNA methyltransferase bin3, C-terminal
• Bin3-type S-adenosyl-L-methionine binding domain
• S-adenosyl-L-methionine-dependent methyltransferase superfamily
• RNA methyltransferase Bin3-like
• Bicoid-interacting protein 3 (Bin3)

KeywordsUniProt

• Cytoplasm
• Methyltransferase
• S-adenosyl-L-methionine
• Transferase

InteractionsUniProt · HPA

Protein binding partners of BCDIN3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DICER1