Seroatlas · Human Serome Atlas

BCAS4

Breast carcinoma-amplified sequence 4

Also known as: BCAS4_HUMAN, CNOL, FLJ20495

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDM0
Gene: BCAS4
Ensembl: ENSG00000124243
Chromosome: 20
Canonical length: 211 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm. Predicted to be part of BLOC-1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q8TDM0|BCAS4
     1  MQRTGGGAPR PGRNHGLPGS LRQPDPVALL MLLVDADQPE PMRSGARELA LFLTPEPGAE
    61  AKEVEETIEG MLLRLEEFCS LADLIRSDTS QILEENIPVL KAKLTEMRGI YAKVDRLEAF
   121  VKMVGHHVAF LEADVLQAER DHGAFPQALR RWLGSAGLPS FRNVECSGTI PARCNLRLPG
   181  SSDSPASASQ VAGITEVTCT GARDVRAAHT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCAS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

tonsil: 39 nTPM
lymph node: 39 nTPM
choroid plexus: 20 nTPM
thymus: 19 nTPM
hippocampal formation: 17 nTPM
basal ganglia: 15 nTPM

Single-cell type

b-cells: 110 nCPM
epididymal clear cells: 57 nCPM
oocytes: 55 nCPM
choroid plexus epithelial cells: 45 nCPM
thymocytes: 42 nCPM
cytotrophoblasts: 40 nCPM

Immune cell

memory B-cell: 109 nTPM
naive B-cell: 106 nTPM
naive CD4 T-cell: 46 nTPM
naive CD8 T-cell: 36 nTPM
NK-cell: 30 nTPM
plasmacytoid DC: 26 nTPM

Brain region

hippocampal formation: 42 nTPM
cerebral cortex: 42 nTPM
choroid plexus: 21 nTPM
basal ganglia: 20 nTPM
white matter: 18 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cappuccino

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCAS4 as an antibody target. Whether an autoantibody or antibody against BCAS4 could matter depends on whether native BCAS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCAS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCAS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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