BBX

Protein identityUniProt · HPA

UniProt accession

Q8WY36

Gene

BBX

Ensembl

ENSG00000114439

Chromosome

3

Canonical length

941 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>Q8WY36|BBX
     1  MKGSNRNKDH SAEGEGVGKR PKRKCLQWHP LLAKKLLDFS EEEEEEDEEE DIDKVQLLGA
    61  DGLEQDVGET EDDESPEQRA RRPMNAFLLF CKRHRSLVRQ EHPRLDNRGA TKILADWWAV
   121  LDPKEKQKYT DMAKEYKDAF MKANPGYKWC PTTNKPVKSP TPTVNPRKKL WAFPSDSSRD
   181  LPSPKKAKTE EMPQLNFGMA DPTQMGGLSM LLLAGEHALG TPEVSSGTCR PDVSESPELR
   241  QKSPLFQFAE ISSSTSHSDA STKQCQTSAL FQFAEISSNT SQLGGAEPVK RCGKSALFQL
   301  AEMCLASEGM KMEESKLIKA KESDGGRIKE LEKGKEEKEI KMEKTDETRL QKEAEFEKSA
   361  KENLRDSKEL RNFEALQIDD IMAIKMEDPK EIRKEELEED HKCSHFPDFS YSASSKIIIS
   421  DVPSRKDHMC HPHGIMIIED PAALNKPEKL KKKKKKSKMD RHGNDKSTPK KTCKKRQSSE
   481  SDIESVIYTI EAVAKGDWGI EKLGDTPRKK VRTSSSGKGS ILDAKPPKKK VKSREKKMSK
   541  EKSSDTTKES RPPDFISISA SKNISGETPE GIKAEPLTPM EDALPPSLSG QAKPEDSDCH
   601  RKIETCGSRK SERSCKGALY KTLVSEGMLT SLRANVDRGK RSSGKGNSSD HEGCWNEESW
   661  TFSQSGTSGS KKFKKTKPKE DCLLGSAKLD EEFEKKFNSL PQYSPVTFDR KCVPVPRKKK
   721  KTGNVSSEPT KTSKGPFQSQ KKNLFHKIVS KYKHKKEKPN VPEKGSGDKW SNKQLFLDAI
   781  HPTEAIFSED RNTMEPVHKV KNIPSIFNTP EPTTTQEPLV GSQKRKARKT KITHLVRTAD
   841  GRVSPAGGTL DDKPKEQLQR SLPKATETDC NDKCSHNTEV GETRSSTPEM PAVSAFFSLA
   901  ALAEVAAMEN VHRGQRSTPL THDGQPKEMP QAPVLISCAD Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BBX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.52

gnomAD missense Z

1.09

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bone development
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• High mobility group box domain
• High mobility group box domain superfamily
• Cell Cycle and Developmental Transcription Regulators
• HMG (high mobility group) box
• HMG box transcription factor BBX, domain of unknown function DUF2028
• HMG box transcription factor BBX, HMG-box domain
• Domain of unknown function (DUF2028)

KeywordsUniProt

• Coiled coil
• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of BBX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HDAC1