Seroatlas · Human Serome Atlas

BASP1

Brain acid soluble protein 1

Also known as: BASP1_HUMAN, CAP-23, CAP23, NAP-22, NAP22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80723
Gene: BASP1
Ensembl: ENSG00000176788
Chromosome: 5
Canonical length: 227 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>P80723|BASP1
     1  MGGKLSKKKK GYNVNDEKAK EKDKKAEGAA TEEEGTPKES EPQAAAEPAE AKEGKEKPDQ
    61  DAEGKAEEKE GEKDAAAAKE EAPKAEPEKT EGAAEAKAEP PKAPEQEQAA PGPAAGGEAP
   121  KAAEAAAAPA ESAAPAAGEE PSKEEGEPKK TEAPAAPAAQ ETKSDGAPAS DSKPGSSEAA
   181  PSSKETPAAT EAPSSTPKAQ GPAASAEEPK PVEAPAANSD QTVTVKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BASP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 380 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 380 nTPM
epididymis: 286 nTPM
hippocampal formation: 216 nTPM
amygdala: 212 nTPM
hypothalamus: 183 nTPM
cerebellum: 130 nTPM

Single-cell type

neutrophils: 6,905 nCPM
neutrophil progenitors: 1,421 nCPM
epididymal principal cells: 1,145 nCPM
syncytiotrophoblasts: 1,088 nCPM
monocytes: 1,051 nCPM
retinal pigment epithelial cells: 882 nCPM

Immune cell

neutrophil: 129 nTPM
eosinophil: 25 nTPM
basophil: 25 nTPM
naive B-cell: 7.9 nTPM
memory B-cell: 5.4 nTPM
myeloid DC: 4.9 nTPM

Brain region

cerebral cortex: 893 nTPM
white matter: 466 nTPM
basal ganglia: 378 nTPM
hippocampal formation: 346 nTPM
hypothalamus: 334 nTPM
pons: 278 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.69
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Brain acid soluble protein 1
Brain acid soluble protein 1 (BASP1 protein)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BASP1 as an antibody target. Whether an autoantibody or antibody against BASP1 could matter depends on whether native BASP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BASP1 is annotated at the cell surface, where native BASP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BASP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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