Seroatlas · Human Serome Atlas

BARX2

Homeobox protein BarH-like 2

Also known as: BARX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMQ3
Gene: BARX2
Ensembl: ENSG00000043039
Chromosome: 11
Canonical length: 279 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q9UMQ3|BARX2
     1  MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS LVVRPKPLHS
    61  CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH QVTEAVSAEA PGGEALASSE
   121  SETEQPTPRQ KKPRRSRTIF TELQLMGLEK KFQKQKYLST PDRLDLAQSL GLTQLQVKTW
   181  YQNRRMKWKK MVLKGGQEAP TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ
   241  EELCEAQEPK ARDVPLEMAE PPDPPQELPI PSSEPPPLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BARX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

esophagus: 143 nTPM
salivary gland: 124 nTPM
vagina: 66 nTPM
cervix: 40 nTPM
tongue: 37 nTPM
skin: 31 nTPM

Single-cell type

lacrimal acinar cells: 1,026 nCPM
salivary acinar cells: 667 nCPM
esophageal suprabasal cells: 516 nCPM
esophageal apical cells: 363 nCPM
pancreatic duct cells: 306 nCPM
salivary ionocytes: 296 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 13 nTPM
medulla oblongata: 8.3 nTPM
white matter: 7.4 nTPM
spinal cord: 5.4 nTPM
midbrain: 5.2 nTPM
pons: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.21
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BARX2 as an antibody target. Whether an autoantibody or antibody against BARX2 could matter depends on whether native BARX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BARX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BARX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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