Seroatlas · Human Serome Atlas

BARX1

Homeobox protein BarH-like 1

Also known as: BARX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBU1
Gene: BARX1
Ensembl: ENSG00000131668
Chromosome: 9
Canonical length: 254 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9HBU1|BARX1
     1  MQRPGEPGAA RFGPPEGCAD HRPHRYRSFM IEEILTEPPG PKGAAPAAAA AAAGELLKFG
    61  VQALLAARPF HSHLAVLKAE QAAVFKFPLA PLGCSGLSSA LLAAGPGLPG AAGAPHLPLE
   121  LQLRGKLEAA GPGEPGTKAK KGRRSRTVFT ELQLMGLEKR FEKQKYLSTP DRIDLAESLG
   181  LSQLQVKTWY QNRRMKWKKI VLQGGGLESP TKPKGRPKKN SIPTSEQLTE QERAKDAEKP
   241  AEVPGEPSDR SRED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BARX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

stomach: 158 nTPM
adipose tissue: 16 nTPM
parathyroid gland: 14 nTPM
testis: 3.8 nTPM
colon: 1.7 nTPM
salivary gland: 1.6 nTPM

Single-cell type

vascular smooth muscle cells: 16 nCPM
fibroblasts: 12 nCPM
salivary basal cells: 3.7 nCPM
early spermatids: 3.5 nCPM
gastric chief cells: 2.2 nCPM
salivary ionocytes: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 1 nTPM
hippocampal formation: 0.2 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.59
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BARX1 as an antibody target. Whether an autoantibody or antibody against BARX1 could matter depends on whether native BARX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BARX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BARX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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