Seroatlas · Human Serome Atlas

BANF2

Barrier-to-autointegration factor-like protein

Also known as: BAF-L, BAF2, BAFL, BAFL_HUMAN, C20orf179, dJ803K15.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H503
Gene
BANF2
Ensembl
ENSG00000125888
Chromosome
20
Canonical length
90 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in chromosome organization. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>Q9H503|BANF2
     1  MDNMSPRLRA FLSEPIGEKD VCWVDGISHE LAINLVTKGI NKAYILLGQF LLMHKNEAEF
    61  QRWLICCFGA TECEAQQTSH CLKEWCACFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BANF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • testis: 107 nTPM
  • pancreas: 19 nTPM
  • choroid plexus: 1.2 nTPM
  • thyroid gland: 1.2 nTPM
  • breast: 0.3 nTPM
  • fallopian tube: 0.3 nTPM

Single-cell type

  • late spermatids: 4,210 nCPM
  • early spermatids: 1,121 nCPM
  • late primary spermatocytes: 154 nCPM
  • endometrial stromal cells: 4.4 nCPM
  • leydig cells: 4.2 nCPM
  • pancreatic acinar cells: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 2 nTPM
  • pons: 0.6 nTPM
  • cerebellum: 0.5 nTPM
  • medulla oblongata: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • hypothalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.01
gnomAD missense Z
0.42
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BANF2 as an antibody target. Whether an autoantibody or antibody against BANF2 could matter depends on whether native BANF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BANF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BANF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BANF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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