BAMBI

Protein identityUniProt · HPA

UniProt accession

Q13145

Gene

BAMBI

Ensembl

ENSG00000095739

Chromosome

10

Canonical length

260 aa

Protein class

Plasma proteins, Predicted membrane proteins

Subcellular location

Nucleoli fibrillar center,Vesicles,Lipid droplets

OverviewNCBI Gene

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q13145|BAMBI
     1  MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN
    61  SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA
   121  SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN
   181  KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND
   241  KILSLVHWGM YSGHGKLEFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAMBI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

59 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.24

gnomAD pLI

0

gnomAD missense Z

-0.1

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell migration
• negative regulation of BMP signaling pathway
• negative regulation of osteoblast differentiation
• negative regulation of transforming growth factor beta receptor signaling pathway
• positive regulation of canonical Wnt signaling pathway
• positive regulation of cell population proliferation
• positive regulation of DNA-templated transcription
• positive regulation of epithelial to mesenchymal transition
• regulation of cell shape
• transforming growth factor beta receptor signaling pathway

Molecular functions

• frizzled binding
• type II transforming growth factor beta receptor binding

Cellular components

• cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Snake toxin-like superfamily
• BMP and activin membrane-bound inhibitor
• BMP and activin membrane-bound inhibitor, C-terminal domain
• BMP and activin membrane-bound inhibitor, N-terminal domain
• BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
• BMP and activin membrane-bound inhibitor homolog C-terminus

KeywordsUniProt

• Glycoprotein
• Membrane
• Signal
• Transmembrane
• Transmembrane helix