Seroatlas · Human Serome Atlas

B3GNTL1

Queuosine-tRNA galactosyltransferase

Also known as: B3GNT8, QTGAL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q67FW5
Gene: B3GNTL1
Ensembl: ENSG00000175711
Chromosome: 17
Canonical length: 346 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Enables tRNA-queuosine(34) galactosyltransferase activity. Involved in regulation of translation and tRNA modification. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q67FW5|B3GNTL1
     1  MQAHVSIILP VHNAEPWLDE CLRSVLQQDF EGTMELSVFN DASKDKSGAI IEKWRVKLED
    61  SGVHVIIGGH DSPSPRGVGY AKNQAVAQSS GSYLCFLDSD DVMMPQRVRL QHEAAVQHPS
   121  SIIGCRVRRD PPNSTERYTR WINQLTPEQL LTQVFTSNGP TVIMPTWFCS RAWFSHVGPF
   181  NEGGQGVPED LLFFYEHLRK GGGVIRVDQS LLLYRHHPQA ATHCVLETTI WTHRVRFLEE
   241  QALPRWAAFT IWNAGKQGRR LYRSLTAGSQ RKVVAFCDVD ENKIRKGFYC HEDSQERPKP
   301  RIPILHFRAA RPPFVICVKL DLTGGAFEDN LRSLHLQEGQ DFLHFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.8 nTPM
basal ganglia: 2.9 nTPM
spleen: 2.7 nTPM
choroid plexus: 2.6 nTPM
cerebral cortex: 2.5 nTPM
hippocampal formation: 2.3 nTPM

Single-cell type

neutrophils: 42 nCPM
choroid plexus epithelial cells: 30 nCPM
late spermatids: 28 nCPM
oocytes: 28 nCPM
epididymal principal cells: 27 nCPM
brain inhibitory neurons: 20 nCPM

Immune cell

neutrophil: 6.2 nTPM
T-reg: 1.4 nTPM
basophil: 1.3 nTPM
classical monocyte: 1.1 nTPM
myeloid DC: 1.1 nTPM
MAIT T-cell: 1 nTPM

Brain region

choroid plexus: 4.2 nTPM
white matter: 3.3 nTPM
cerebral cortex: 2.9 nTPM
thalamus: 2.8 nTPM
hippocampal formation: 2.7 nTPM
basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tRNA-queuosine(34) galactosyltransferase activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GNTL1 as an antibody target. Whether an autoantibody or antibody against B3GNTL1 could matter depends on whether native B3GNTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GNTL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GNTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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