Seroatlas · Human Serome Atlas

B3GNT9

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

Also known as: B3GN9_HUMAN, MGC4655

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX72
Gene: B3GNT9
Ensembl: ENSG00000237172
Chromosome: 16
Canonical length: 402 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Golgi apparatus
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q6UX72|B3GNT9
     1  MRRRLRLRRD ALLTLLLGAS LGLLLYAQRD GAAPTASAPR GRGRAAPRPT PGPRAFQLPD
    61  AGAAPPAYEG DTPAPPTPTG PFDFARYLRA KDQRRFPLLI NQPHKCRGDG APGGRPDLLI
   121  AVKSVAEDFE RRQAVRQTWG AEGRVQGALV RRVFLLGVPR GAGSGGADEV GEGARTHWRA
   181  LLRAESLAYA DILLWAFDDT FFNLTLKEIH FLAWASAFCP DVRFVFKGDA DVFVNVGNLL
   241  EFLAPRDPAQ DLLAGDVIVH ARPIRTRASK YYIPEAVYGL PAYPAYAGGG GFVLSGATLH
   301  RLAGACAQVE LFPIDDVFLG MCLQRLRLTP EPHPAFRTFG IPQPSAAPHL STFDPCFYRE
   361  LVVVHGLSAA DIWLMWRLLH GPHGPACAHP QPVAAGPFQW DS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNT9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 21 nTPM
parathyroid gland: 21 nTPM
blood vessel: 20 nTPM
thyroid gland: 19 nTPM
ovary: 16 nTPM
cervix: 16 nTPM

Single-cell type

breast lactating cells: 17 nCPM
peritubular myoid cells: 16 nCPM
late spermatids: 11 nCPM
fibroblasts: 11 nCPM
leydig cells: 11 nCPM
epididymal basal cells: 10 nCPM

Immune cell

memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

white matter: 20 nTPM
midbrain: 18 nTPM
spinal cord: 17 nTPM
medulla oblongata: 16 nTPM
choroid plexus: 15 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GNT9 as an antibody target. Whether an autoantibody or antibody against B3GNT9 could matter depends on whether native B3GNT9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GNT9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GNT9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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