Seroatlas · Human Serome Atlas

B3GNT7

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Also known as: B3GN7_HUMAN, beta3GnT7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFL0
Gene: B3GNT7
Ensembl: ENSG00000156966
Chromosome: 2
Canonical length: 401 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables acetylglucosaminyltransferase activity. Involved in keratan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q8NFL0|B3GNT7
     1  MSLWKKTVYR SLCLALALLV AVTVFQRSLT PGQFLQEPPP PTLEPQKAQK PNGQLVNPNN
    61  FWKNPKDVAA PTPMASQGPQ AWDVTTTNCS ANINLTHQPW FQVLEPQFRQ FLFYRHCRYF
   121  PMLLNHPEKC RGDVYLLVVV KSVITQHDRR EAIRQTWGRE RQSAGGGRGA VRTLFLLGTA
   181  SKQEERTHYQ QLLAYEDRLY GDILQWGFLD TFFNLTLKEI HFLKWLDIYC PHVPFIFKGD
   241  DDVFVNPTNL LEFLADRQPQ ENLFVGDVLQ HARPIRRKDN KYYIPGALYG KASYPPYAGG
   301  GGFLMAGSLA RRLHHACDTL ELYPIDDVFL GMCLEVLGVQ PTAHEGFKTF GISRNRNSRM
   361  NKEPCFFRAM LVVHKLLPPE LLAMWGLVHS NLTCSRKLQV L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

rectum: 67 nTPM
colon: 53 nTPM
stomach: 34 nTPM
small intestine: 27 nTPM
pancreas: 24 nTPM
duodenum: 24 nTPM

Single-cell type

colonocytes: 394 nCPM
enteric stem cells: 195 nCPM
enteric transient amplifying cells: 186 nCPM
foveolar cells: 117 nCPM
extravillous trophoblasts: 102 nCPM
goblet cells: 89 nCPM

Immune cell

NK-cell: 32 nTPM
memory B-cell: 9.9 nTPM
naive B-cell: 7 nTPM
myeloid DC: 6.5 nTPM
plasmacytoid DC: 3.1 nTPM
gdT-cell: 2.9 nTPM

Brain region

midbrain: 16 nTPM
thalamus: 16 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 13 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.71
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GNT7 as an antibody target. Whether an autoantibody or antibody against B3GNT7 could matter depends on whether native B3GNT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GNT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GNT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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