Seroatlas · Human Serome Atlas

B3GNT4

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

Also known as: B3GN-T4, B3GN4_HUMAN, beta3Gn-T4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0J1
Gene: B3GNT4
Ensembl: ENSG00000176383
Chromosome: 12
Canonical length: 378 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q9C0J1|B3GNT4
     1  MLPPQPSAAH QGRGGRSGLL PKGPAMLCRL CWLVSYSLAV LLLGCLLFLR KAAKPAGDPT
    61  AHQPFWAPPT PRHSRCPPNH TVSSASLSLP SRHRLFLTYR HCRNFSILLE PSGCSKDTFL
   121  LLAIKSQPGH VERRAAIRST WGRVGGWARG RQLKLVFLLG VAGSAPPAQL LAYESREFDD
   181  ILQWDFTEDF FNLTLKELHL QRWVVAACPQ AHFMLKGDDD VFVHVPNVLE FLDGWDPAQD
   241  LLVGDVIRQA LPNRNTKVKY FIPPSMYRAT HYPPYAGGGG YVMSRATVRR LQAIMEDAEL
   301  FPIDDVFVGM CLRRLGLSPM HHAGFKTFGI RRPLDPLDPC LYRGLLLVHR LSPLEMWTMW
   361  ALVTDEGLKC AAGPIPQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.9 nTPM
cerebral cortex: 4.2 nTPM
basal ganglia: 2.9 nTPM
hippocampal formation: 2.9 nTPM
skin: 2.6 nTPM
kidney: 2.3 nTPM

Single-cell type

oocytes: 166 nCPM
epicardial cells: 16 nCPM
cardiomyocytes: 12 nCPM
esophageal apical cells: 8.2 nCPM
brain excitatory neurons: 7.8 nCPM
other brain neurons: 7 nCPM

Immune cell

non-classical monocyte: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 17 nTPM
hippocampal formation: 15 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
amygdala: 11 nTPM
white matter: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -2.4
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GNT4 as an antibody target. Whether an autoantibody or antibody against B3GNT4 could matter depends on whether native B3GNT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GNT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GNT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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