Seroatlas · Human Serome Atlas

B3GALT9

Beta-1,3-galactosyltransferase 9

Also known as: B3GNT10, B3GT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MXE2
Gene: B3GALT9
Ensembl: ENSG00000214654
Chromosome: 9
Canonical length: 369 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable glycosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>A8MXE2|B3GALT9
     1  MQVTFCRLRT HQWCFILFNV ILFHALLFGT DFVEEYFLHS LPYIDVKVLE IKNKARKLNI
    61  EPLRSNLSKY YVLSQSEICK GKNIFLLSLI FSSPGNGTRR DLIRKTWGNV TSVQGHPILT
   121  LFALGMPVSV TTQKEINKES CKNNDIIEGI FLDSSENQTL KIIAMIQWAV AFCPNALFIL
   181  KVDEETFVNL PSLVDYLLNL KEHLEDIYVG RVLHQVTPNR DPQNRDFVPL SEYPEKYYPD
   241  YCSGEAFIMS QDVARMMYVV FKEVPMMVPA DVFVGICAKF IGLIPIHSSR FSGKRHIRYN
   301  RCCYKFIFTS SEIADPEMPL AWKEINDGKE CTLFETSYEL ISCKLLTYLD SFKRFHMGTI
   361  KNNLMYFAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GALT9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.7 nTPM
epididymis: 3.1 nTPM
lymph node: 3 nTPM
thyroid gland: 2.9 nTPM
kidney: 2.6 nTPM
stomach: 2.6 nTPM

Single-cell type

cardiomyocytes: 61 nCPM
late spermatids: 48 nCPM
epicardial cells: 30 nCPM
early spermatids: 18 nCPM
adipocytes: 15 nCPM
tuft cells: 12 nCPM

Immune cell

NK-cell: 2.2 nTPM
eosinophil: 1.8 nTPM
gdT-cell: 1.8 nTPM
naive CD4 T-cell: 1.8 nTPM
memory CD8 T-cell: 1.7 nTPM
T-reg: 1.7 nTPM

Brain region

white matter: 13 nTPM
cerebellum: 10 nTPM
choroid plexus: 9.7 nTPM
basal ganglia: 9 nTPM
medulla oblongata: 8.9 nTPM
pons: 8.7 nTPM

OntologyGO

Biological processes

protein O-linked glycosylation

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GALT9 as an antibody target. Whether an autoantibody or antibody against B3GALT9 could matter depends on whether native B3GALT9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GALT9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GALT9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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