Seroatlas · Human Serome Atlas

B3GALT5

Beta-1,3-galactosyltransferase 5

Also known as: B3GalT-V, B3GT5_HUMAN, B3T5, beta3Gal-T5, GLCT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2C3
Gene: B3GALT5
Ensembl: ENSG00000183778
Chromosome: 21
Canonical length: 310 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q9Y2C3|B3GALT5
     1  MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT DCRQTPPFLV
    61  LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT SSAAETKEVD QESQRHGDII
   121  QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA FVMKTDSDMF INVDYLTELL LKKNRTTRFF
   181  TGFLKLNEFP IRQPFSKWFV SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK
   241  LEDVFVGLCL ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE
   301  NSRGEDCPPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GALT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

small intestine: 43 nTPM
rectum: 37 nTPM
duodenum: 34 nTPM
colon: 22 nTPM
gallbladder: 5.1 nTPM
stomach: 4.7 nTPM

Single-cell type

choroid plexus epithelial cells: 81 nCPM
pituitary stem cells: 75 nCPM
thyrotrophs: 69 nCPM
papillary tip epithelial cells: 69 nCPM
somatotrophs: 64 nCPM
ependymal cells: 51 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 26 nTPM
hypothalamus: 22 nTPM
hippocampal formation: 9.4 nTPM
choroid plexus: 9.3 nTPM
midbrain: 9.2 nTPM
cerebral cortex: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

3)-galactosyltransferase activity
N-acetyl-beta-D-glucosaminide beta-(1

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GALT5 as an antibody target. Whether an autoantibody or antibody against B3GALT5 could matter depends on whether native B3GALT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GALT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GALT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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