Seroatlas · Human Serome Atlas

B3GALT2

Beta-1,3-galactosyltransferase 2

Also known as: B3GT2_HUMAN, beta3Gal-T2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43825
Gene
B3GALT2
Ensembl
ENSG00000162630
Chromosome
1
Canonical length
422 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>O43825|B3GALT2
     1  MLQWRRRHCC FAKMTWNAKR SLFRTHLIGV LSLVFLFAMF LFFNHHDWLP GRAGFKENPV
    61  TYTFRGFRST KSETNHSSLR NIWKETVPQT LRPQTATNSN NTDLSPQGVT GLENTLSANG
   121  SIYNEKGTGH PNSYHFKYII NEPEKCQEKS PFLILLIAAE PGQIEARRAI RQTWGNESLA
   181  PGIQITRIFL LGLSIKLNGY LQRAILEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT
   241  YCPHIPYVMK TDSDMFVNTE YLINKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP
   301  DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK LRIDPVPPPN
   361  EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN KHNACANAAK EKAGRYRHRK
   421  LH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GALT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 20 nTPM
  • cerebral cortex: 15 nTPM
  • gallbladder: 14 nTPM
  • ovary: 8.3 nTPM
  • amygdala: 6.4 nTPM
  • hippocampal formation: 6.3 nTPM

Single-cell type

  • epicardial cells: 50 nCPM
  • cardiomyocytes: 43 nCPM
  • retinal bipolar cells: 34 nCPM
  • leydig cells: 34 nCPM
  • oligodendrocyte progenitor cells: 20 nCPM
  • other brain neurons: 20 nCPM

Immune cell

  • MAIT T-cell: 8.4 nTPM
  • memory CD4 T-cell: 1.9 nTPM
  • T-reg: 1.8 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • gdT-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM

Brain region

  • cerebral cortex: 35 nTPM
  • white matter: 32 nTPM
  • basal ganglia: 28 nTPM
  • hippocampal formation: 18 nTPM
  • thalamus: 17 nTPM
  • midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.9
gnomAD missense Z
1.62
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GALT2 as an antibody target. Whether an autoantibody or antibody against B3GALT2 could matter depends on whether native B3GALT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GALT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GALT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/B3GALT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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