Seroatlas · Human Serome Atlas

AXDND1

Axonemal dynein light chain domain-containing protein 1

Also known as: AXDN1_HUMAN, C1orf125, FLJ32940

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1B0
Gene: AXDND1
Ensembl: ENSG00000162779
Chromosome: 1
Canonical length: 1012 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Predicted to be involved in manchette assembly. Located in ciliary basal body and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1012 residues, UniProt reviewed canonical sequence.

>Q5T1B0|AXDND1
     1  MSLPKTPSTP LNSTSTSESK KLKVSVAKEG TRGLPELKEK KNMVDRSKLL PTSLQNEFIP
    61  KEVLLSLTYA ANAGPCPENL LPPKKIKTPK GTLPRLVDHV WHHPVRRNKF KYLIDHPVSL
   121  TGAGRDISFL YDVTYAKGQT REKAVCPPHL ARSLQSHDGV IVPHKPKTLT DTLIPEEFHI
   181  VSSTGVSGLE CYDDKYTTLL TDSENRLLLF PSMKPNKRVE VAQLNDVMDT MLERAGVENQ
   241  EYTGPTKMHK LLHILKKEQT IYNMIFHELI RQVSVDCADR GELLSKVRER YVQMLDQIAR
   301  QMIDFYKDLV TQRVMDQRIL EELYNFKHVI EELTRELCLV RAHDVKLTKE TEKAHKDLAQ
   361  ALLNAEKNAK IVEEYHDLYT LQRERMENDM KKLVAERDIW SSATYELALK VIERNRVILA
   421  RRLYLNEKGW NKYTKHFIIL LSNKDTEDLA LLQKLTQKWR NLVNKLKQEV EQMEESTSET
   481  LKIVKDGLIK WQEFFNEKDI LSPNKGNIFN SVLLDFKQWQ KILNEKKEEF TGDVLLSKYD
   541  TLKIIKHLQE NWADIGLGIF NRHKSLEGEM PSERQYMEEI IKNIQKLYKE YEIRINGDNG
   601  YSKILPSLIS SLDFCSFKLE NLEFPDTPLE EWQEIDEKIN EMKSHLDILL NLTGIVPQHI
   661  DVDSVSVLQA YIFNMIQQWL LKIGNEINNG NIELQHHMDE LHISMIQWMV NLLILMIPNF
   721  TDQDCLLKLE EESAEKHDIG VARLELDAIE LTRKLYQYSS YLSSCCKGMV TAMALSKSTN
   781  SHKNATEDLY EVDKLKKECY EWINTCSCLL SNIKGRKITL LTYEEIERLL EEEAVKEFIE
   841  PEIDESFKED EEESKEDRKL QEENKERAEE QPSTSTEKEK LIRFIGEDEN VHSKPLFETD
   901  VLSSWRESAK QGTLAQKYLE AMAVIEHMQE KLLEVENRAR QAEEKFEDAY EKLHHTLIKN
   961  KDLEELVMTS RKESKEEKEN QDEREVKEEE EQQEEEEVRS AENSSKSPKK GH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AXDND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
epididymis: 0.4 nTPM
adrenal gland: 0.3 nTPM
choroid plexus: 0.3 nTPM
colon: 0.2 nTPM
fallopian tube: 0.2 nTPM

Single-cell type

late spermatids: 425 nCPM
late primary spermatocytes: 246 nCPM
early spermatids: 242 nCPM
ependymal cells: 93 nCPM
foveolar cells: 62 nCPM
podocytes: 49 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 1 nTPM
choroid plexus: 0.9 nTPM
spinal cord: 0.9 nTPM
medulla oblongata: 0.7 nTPM
white matter: 0.7 nTPM
basal ganglia: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AXDND1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 156 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Non-obstructive azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Axonemal dynein light chain
Axonemal dynein light chain
Axonemal dynein light chain domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AXDND1 as an antibody target. Whether an autoantibody or antibody against AXDND1 could matter depends on whether native AXDND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AXDND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AXDND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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