Seroatlas · Human Serome Atlas

AVPI1

Arginine vasopressin-induced protein 1

Also known as: AVPI1_HUMAN, PP5395, VIP32, VIT32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T686
Gene
AVPI1
Ensembl
ENSG00000119986
Chromosome
10
Canonical length
147 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in positive regulation of MAPK cascade. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q5T686|AVPI1
     1  MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL AEERAQIIWE
    61  CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP HSALANPQSA TETASSEQYL
   121  HSRKKSARIR RNWRKSGPTS YLHQIRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AVPI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • skin: 105 nTPM
  • ovary: 86 nTPM
  • blood vessel: 57 nTPM
  • liver: 47 nTPM
  • adrenal gland: 46 nTPM
  • vagina: 46 nTPM

Single-cell type

  • late spermatids: 477 nCPM
  • syncytiotrophoblasts: 264 nCPM
  • esophageal apical cells: 230 nCPM
  • cytotrophoblasts: 195 nCPM
  • müller glia: 153 nCPM
  • colonocytes: 153 nCPM

Immune cell

  • myeloid DC: 11 nTPM
  • classical monocyte: 6.2 nTPM
  • intermediate monocyte: 5.7 nTPM
  • gdT-cell: 4.2 nTPM
  • naive CD8 T-cell: 3.7 nTPM
  • memory CD8 T-cell: 3.1 nTPM

Brain region

  • white matter: 42 nTPM
  • cerebral cortex: 33 nTPM
  • medulla oblongata: 30 nTPM
  • spinal cord: 28 nTPM
  • pons: 26 nTPM
  • cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AVPI1 as an antibody target. Whether an autoantibody or antibody against AVPI1 could matter depends on whether native AVPI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AVPI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AVPI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AVPI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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