Seroatlas · Human Serome Atlas

AVL9

Late secretory pathway protein AVL9 homolog

Also known as: AVL9_HUMAN, KIAA0241

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBF6
Gene: AVL9
Ensembl: ENSG00000105778
Chromosome: 7
Canonical length: 648 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Involved in cell migration. Located in recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q8NBF6|AVL9
     1  MEKARRGGDG VPRGPVLHIV VVGFHHKKGC QVEFSYPPLI PGDGHDSHTL PEEWKYLPFL
    61  ALPDGAHNYQ EDTVFFHLPP RNGNGATVFG ISCYRQIEAK ALKVRQADIT RETVQKSVCV
   121  LSKLPLYGLL QAKLQLITHA YFEEKDFSQI SILKELYEHM NSSLGGASLE GSQVYLGLSP
   181  RDLVLHFRHK VLILFKLILL EKKVLFYISP VNKLVGALMT VLSLFPGMIE HGLSDCSQYR
   241  PRKSMSEDGG LQESNPCADD FVSASTADVS HTNLGTIRKV MAGNHGEDAA MKTEEPLFQV
   301  EDSSKGQEPN DTNQYLKPPS RPSPDSSESD WETLDPSVLE DPNLKEREQL GSDQTNLFPK
   361  DSVPSESLPI TVQPQANTGQ VVLIPGLISG LEEDQYGMPL AIFTKGYLCL PYMALQQHHL
   421  LSDVTVRGFV AGATNILFRQ QKHLSDAIVE VEEALIQIHD PELRKLLNPT TADLRFADYL
   481  VRHVTENRDD VFLDGTGWEG GDEWIRAQFA VYIHALLAAT LQLDNEKILS DYGTTFVTAW
   541  KNTHNYRVWN SNKHPALAEI NPNHPFQGQY SVSDMKLRFS HSVQNSERGK KIGNVMVTTS
   601  RNVVQTGKAV GQSVGGAFSS AKTAMSSWLS TFTTSTSQSL TEPPDEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AVL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

retina: 20 nTPM
rectum: 16 nTPM
colon: 14 nTPM
cerebral cortex: 14 nTPM
duodenum: 12 nTPM
small intestine: 12 nTPM

Single-cell type

neutrophils: 384 nCPM
neutrophil progenitors: 325 nCPM
microglia: 179 nCPM
proximal tubule cells: 176 nCPM
choroid plexus epithelial cells: 175 nCPM
thyrotrophs: 169 nCPM

Immune cell

neutrophil: 13 nTPM
eosinophil: 8.8 nTPM
basophil: 8.4 nTPM
naive B-cell: 5.7 nTPM
total PBMC: 5.7 nTPM
classical monocyte: 5.6 nTPM

Brain region

hypothalamus: 34 nTPM
cerebral cortex: 33 nTPM
basal ganglia: 33 nTPM
pons: 30 nTPM
choroid plexus: 29 nTPM
hippocampal formation: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AVL9.

Disease | ImmuneIEDB

Conditions an epitope on AVL9 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 1.27
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell migration

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AVL9 as an antibody target. Whether an autoantibody or antibody against AVL9 could matter depends on whether native AVL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AVL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AVL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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