Seroatlas · Human Serome Atlas

AVEN

Cell death regulator Aven

Also known as: AVEN_HUMAN, PDCD12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQS1
Gene: AVEN
Ensembl: ENSG00000169857
Chromosome: 15
Canonical length: 362 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Centrosome

OverviewNCBI Gene

Involved in negative regulation of apoptotic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q9NQS1|AVEN
     1  MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR
    61  GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR
   121  YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS
   181  ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP
   241  IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD
   301  NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM
   361  IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AVEN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 31 nTPM
skeletal muscle: 29 nTPM
heart muscle: 26 nTPM
pancreas: 19 nTPM
liver: 15 nTPM
colon: 14 nTPM

Single-cell type

oocytes: 428 nCPM
choroid plexus epithelial cells: 104 nCPM
proximal tubule cells: 100 nCPM
thymocytes: 98 nCPM
adipocytes: 89 nCPM
megakaryocyte-erythroid progenitors: 88 nCPM

Immune cell

plasmacytoid DC: 2.3 nTPM
T-reg: 0.9 nTPM
intermediate monocyte: 0.6 nTPM
MAIT T-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

choroid plexus: 10 nTPM
pons: 8 nTPM
hypothalamus: 7.8 nTPM
medulla oblongata: 7.4 nTPM
thalamus: 7.4 nTPM
midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -2.13
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cell death regulator Aven

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AVEN as an antibody target. Whether an autoantibody or antibody against AVEN could matter depends on whether native AVEN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AVEN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AVEN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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