Seroatlas · Human Serome Atlas

ATXN8OS

Putative protein ATXN8OS

Also known as: AT8OS_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DMR3
Gene: ATXN8OS
Canonical length: 200 aa

OverviewNCBI Gene

No narrative summary is available for ATXN8OS in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>P0DMR3|ATXN8OS
     1  MPCPGAPCCS LVATGSRVPF SGLKEEEEED GEDDEEEEEE GFFQKVLTPL LSWLLSRRLW
    61  LGPQCSKLPL PSCCRQPPPA GPPVEGDGWL KSFQRSRRMC FTSKSFRPEP DMLYAQKAKG
   121  WQLTQDSGGW EVQDQCTRIW SKENLLALNT HSRRQKGKRE NKVCVSTWQK SRGDRTYSSM
   181  ATTPSMTKIL EGCMYRKLKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATXN8OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATXN8OS as an antibody target. Whether an autoantibody or antibody against ATXN8OS could matter depends on whether native ATXN8OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATXN8OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATXN8OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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