Seroatlas · Human Serome Atlas

ATXN8

Ataxin-8

Also known as: ATX8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q156A1
Gene: ATXN8
Canonical length: 80 aa

OverviewNCBI Gene

No narrative summary is available for ATXN8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

80 residues, UniProt reviewed canonical sequence.

>Q156A1|ATXN8
     1  MQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
    61  QQQQQQQQQQ QQQQQQQQQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATXN8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATXN8.

Disease | AllUniProt

Conditions ATXN8 is implicated in, by any mechanism.

Spinocerebellar ataxia 8 (SCA8) MIM:608768

OntologyGO

Cellular components

nucleus

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATXN8 as an antibody target. Whether an autoantibody or antibody against ATXN8 could matter depends on whether native ATXN8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATXN8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATXN8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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