ATPSCKMT
ATP synthase subunit C lysine N-methyltransferase
Also known as: ACKMT_HUMAN, FAM173B, JS-2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P4H8
- Gene
- ATPSCKMT
- Ensembl
- ENSG00000150756
- Chromosome
- 5
- Canonical length
- 233 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Enables protein-lysine N-methyltransferase activity. Involved in several processes, including peptidyl-lysine trimethylation; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; and positive regulation of sensory perception of pain. Located in mitochondrial crista. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
233 residues, UniProt reviewed canonical sequence.
>Q6P4H8|ATPSCKMT
1 MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA VYAVATPFVT
61 PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG RIVIAAAKKG FTAVGYELNP
121 WLVWYSRYRA WREGVHGSAK FYISDLWKVT FSQYSNVVIF GVPQMMLQLE KKLERELEDD
181 ARVIACRFPF PHWTPDHVTG EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATPSCKMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 16 nTPM
- hypothalamus: 12 nTPM
- midbrain: 12 nTPM
- adrenal gland: 9.3 nTPM
- liver: 9.3 nTPM
- spinal cord: 9.3 nTPM
Single-cell type
- ependymal cells: 60 nCPM
- other brain neurons: 53 nCPM
- corticotrophs: 53 nCPM
- choroid plexus epithelial cells: 48 nCPM
- pituicytes/fscs: 46 nCPM
- thyrotrophs: 46 nCPM
Immune cell
- eosinophil: 8.1 nTPM
- intermediate monocyte: 6.7 nTPM
- classical monocyte: 5.8 nTPM
- myeloid DC: 5.8 nTPM
- non-classical monocyte: 5.5 nTPM
- memory CD8 T-cell: 5.4 nTPM
Brain region
- hypothalamus: 24 nTPM
- white matter: 23 nTPM
- choroid plexus: 23 nTPM
- midbrain: 23 nTPM
- cerebellum: 22 nTPM
- medulla oblongata: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.66
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- peptidyl-lysine methylation
- peptidyl-lysine trimethylation
- positive regulation of sensory perception of pain
- regulation of mitochondrial ATP synthesis coupled proton transport
- positive regulation of proton-transporting ATP synthase activity, rotational mechanism
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATPSCKMT as an antibody target. Whether an autoantibody or antibody against ATPSCKMT could matter depends on whether native ATPSCKMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATPSCKMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATPSCKMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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