ATP6V1G3

Protein identityUniProt · HPA

UniProt accession

Q96LB4

Gene

ATP6V1G3

Ensembl

ENSG00000151418

Chromosome

1

Canonical length

118 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q96LB4|ATP6V1G3
     1  MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ RDKEFRLKQS
    61  KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL SMVCDMKPEI HVNYRATN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V1G3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

66 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0.11

gnomAD missense Z

0.25

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• synaptic vesicle lumen acidification

Molecular functions

• ATP hydrolysis activity
• ATPase binding
• proton-transporting ATPase activity, rotational mechanism

Cellular components

• cytosol
• plasma membrane
• synaptic vesicle membrane
• vacuolar proton-transporting V-type ATPase, V1 domain

Protein domainsUniProt · Pfam · InterPro

• Vacuolar (H+)-ATPase G subunit
• Vacuolar (H+)-ATPase G subunit

KeywordsUniProt

• Coiled coil
• Hydrogen ion transport
• Ion transport
• Transport