Seroatlas · Human Serome Atlas

ATP6V0E2

V-type proton ATPase subunit e 2

Also known as: ATP6V0E2L, C7orf32, VA0E2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHE4
Gene: ATP6V0E2
Ensembl: ENSG00000171130
Chromosome: 7
Canonical length: 81 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>Q8NHE4|ATP6V0E2
     1  MTAHSFALPV IIFTTFWGLV GIAGPWFVPK GPNRGVIITM LVATAVCCYL FWLIAILAQL
    61  NPLFGPQLKN ETIWYVRFLW E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V0E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 374 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 374 nTPM
cerebellum: 340 nTPM
cerebral cortex: 329 nTPM
amygdala: 315 nTPM
midbrain: 299 nTPM
basal ganglia: 296 nTPM

Single-cell type

retinal pigment epithelial cells: 188 nCPM
other brain neurons: 141 nCPM
brain excitatory neurons: 120 nCPM
müller glia: 117 nCPM
brain inhibitory neurons: 98 nCPM
retinal bipolar cells: 87 nCPM

Immune cell

T-reg: 91 nTPM
naive CD4 T-cell: 71 nTPM
naive CD8 T-cell: 65 nTPM
memory CD4 T-cell: 55 nTPM
memory CD8 T-cell: 52 nTPM
gdT-cell: 46 nTPM

Brain region

hippocampal formation: 449 nTPM
pons: 439 nTPM
thalamus: 410 nTPM
midbrain: 386 nTPM
medulla oblongata: 376 nTPM
cerebral cortex: 371 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.3
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6V0E2 as an antibody target. Whether an autoantibody or antibody against ATP6V0E2 could matter depends on whether native ATP6V0E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6V0E2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6V0E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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