Seroatlas · Human Serome Atlas

ATP6AP1L

V-type proton ATPase subunit S1-like protein

Also known as: VAS1L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52LC2
Gene: ATP6AP1L
Canonical length: 224 aa

OverviewNCBI Gene

No narrative summary is available for ATP6AP1L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q52LC2|ATP6AP1L
     1  MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY NKLSIQSWFS
    61  LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD QALLLPSDTD DGSSLWEVTF
   121  IDFQIQGFAI KGGRFTKAQD CASSFSPAFL IGLAMSLILL LVLAYALHML IYLRYLDQQY
   181  DLIASPAHFS QLKARDTAEE KELLRSQGAE CYKLRSQQIS KIYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6AP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.03
gnomAD missense Z: 0.34

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasmic vesicle membrane
endomembrane system
bounding membrane of organelle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6AP1L as an antibody target. Whether an autoantibody or antibody against ATP6AP1L could matter depends on whether native ATP6AP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6AP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6AP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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