ATP5MK
ATP synthase F(0) complex subunit k, mitochondrial
Also known as: AGP, ATP5MD, ATPMK_HUMAN, bA792D24.4, DAPIT, MGC14697, USMG5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96IX5
- Gene
- ATP5MK
- Ensembl
- ENSG00000173915
- Chromosome
- 10
- Canonical length
- 58 aa
- Protein class
- Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
- Quaternary structure
- Homooctamer
OverviewNCBI Gene
Predicted to be involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex. Implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 6. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
58 residues, UniProt reviewed canonical sequence.
>Q96IX5|ATP5MK
1 MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK KTPAVKATLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATP5MK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 1,235 nTPM
Expression across tissuesHPA
Tissue
- tongue: 1,235 nTPM
- heart muscle: 1,165 nTPM
- skeletal muscle: 956 nTPM
- amygdala: 723 nTPM
- cerebral cortex: 650 nTPM
- kidney: 576 nTPM
Single-cell type
- parietal cells: 6,412 nCPM
- hepatocytes: 2,168 nCPM
- esophageal apical cells: 1,870 nCPM
- esophageal suprabasal cells: 1,633 nCPM
- colonocytes: 1,412 nCPM
- gastric chief cells: 1,236 nCPM
Immune cell
- basophil: 579 nTPM
- plasmacytoid DC: 458 nTPM
- eosinophil: 398 nTPM
- intermediate monocyte: 386 nTPM
- non-classical monocyte: 378 nTPM
- myeloid DC: 315 nTPM
Brain region
- hypothalamus: 231 nTPM
- cerebral cortex: 201 nTPM
- white matter: 186 nTPM
- basal ganglia: 181 nTPM
- choroid plexus: 181 nTPM
- cerebellum: 179 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ATP5MK.
Disease | AllUniProt
Conditions ATP5MK is implicated in, by any mechanism.
- Mitochondrial complex V deficiency, nuclear type 6 (MC5DN6) MIM:618683
Disease | GeneticClinVar
3 pathogenic / likely-pathogenic of 20 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Mitochondrial complex 5 (ATP synthase) deficiency, nuclear type 6
- Sarcoma
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0.05
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ATP synthase membrane subunit K
- ATP synthase regulation
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATP5MK as an antibody target. Whether an autoantibody or antibody against ATP5MK could matter depends on whether native ATP5MK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATP5MK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATP5MK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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